非霍奇金淋巴瘤化疗患者癌因性疲乏的影响因素分析及有氧运动的干预效果研究

Analysis of the Influencing Factors of Cancer-Related Fatigue in Patients with Non Hodgkin's Lymphoma Chemotherapy and the Intervention Effect of Aerobic Exercise

目的:分析非霍奇金淋巴瘤(NHL)化疗患者癌因性疲乏(CRF)的影响因素,并探讨有氧运动针对NHL化疗患者CRF的干预效果。方法:选择2021年3月至2022年4月期间空军军医大学第一附属医院收治的NHL化疗患者142例,采用自制调查问卷对研究对象进行资料收集,共发放问卷142份,回收问卷142份,其中有效问卷138份,有效回收率为97.18%。根据是否发生CRF分为CRF组(n=109)和无CRF组(n=29),采用单因素和多因素Logistic回归分析NHL化疗患者CRF的影响因素。对NHL化疗后存在CRF的患者给予有氧运动干预,比较干预前后患者的CRF、抑郁和焦虑程度。结果:通过对138例NHL患者的CRF现状进行调查,其中有109例发生CRF,发生率为78.99%。单因素分析显示:NHL化疗患者CRF的发生与就业情况、肿瘤分期、化疗周期、社会支持程度、汉密尔顿抑郁量表(HAMD)评分、汉密尔顿焦虑量表(HAMA)评分有关(P<0.05)。多因素Logistic回归分析结果显示:肿瘤分期为IV期、化疗周期第3~4周期、HAMD评分偏高、HAMA评分偏高是NHL化疗患者CRF发生的危险因素,社会支持程度高则是其保护因素(P<0.05)。干预后,CRF组的感知维度、行为维度、认知维度、情感维度、总分均较干预前下降(P<0.05)。干预后,CRF组的HAMA、HAMD评分均较干预前下降(P<0.05)。结论:NHL化疗患者发生CRF受到化疗周期、HAMD评分、HAMA评分、社会支持程度高等因素的影响,且坚持有氧运动可减轻疲乏程度,缓解抑郁焦虑状况。

Objective:To analyze the influencing factors of cancer-related fatigue(CRF)in patients with non Hodgkin lymphoma(NHL)chemotherapy,and to explore the intervention effect of aerobic exercise on CRF in patients with NHL chemotherapy.Methods:142 cases of patients with NHL chemotherapy who were admitted to The First Affiliated Hospital of Air Force Military Medical University from March 2021 to April 2022 were selected,the self-made questionnaire was used to collect data from the research subjects,a total of142 questionnaires were distributed,and 142 questionnaires were recovered,among which 138 were valid,the effective recovery rate was97.18%.According to the occurrence of CRF,patients were divided into CRF group(n=109)and non-CRF group(n=29).Multivariate Logistic regression was used to analyze the influencing factors of patients with CRF after NHL chemotherapy.Patients with CRF after NHL chemotherapy were given aerobic exercise intervention,and the CRF,depression and anxiety degree of patients were compared before and after intervention.Results:The CRF status of 138 patients with NHL was investigated,109 of them had occurrence of CRF,the incidence rate was 78.99%.Univariate analysis showed that the occurrence of CRF in patients with NHL chemotherapy were related to employment situation,tumor stage,chemotherapy cycle,social support degree,Hamilton Depression Scale(HAMD)score,Hamilton Anxiety Scale(HAMA)score(P<0.05).The results of multivariate Logistic regression analysis showed that tumor with stage IV,3~4 cycles of chemotherapy cycle,high HAMD score and high HAMA score were risk factors for CRF in patients with NHL chemotherapy,and high social support degree was a protective factor(P<0.05).After intervention,the perceptual dimension,behavioral dimension,cognitive dimension,affective dimension,and total score in the CRF group were all decreased compared with those before intervention(P<0.05).After intervention,HAMA and HAMD scores in the CRF group were decreased compared with those before intervention(P<0.05).Conclusion:The occurrence of CRF in patients with NHL chemotherapy is affected by factors such as chemotherapy cycle,HAMD score,HAMA score,and and high social support degree.And adhere to aerobic exercise can reduce fatigue,relieve depression and anxiety status.