孟德尔随机化分析在重症医学领域应用的研究进展

Research progress of Mendelian randomization analysis in intensive care medicine

危重症患者病情变化迅速,涉及全身多系统、多器官的病理学改变。探明机制作用的因果关系能进一步揭示疾病相关病因、治疗和预后,但在危重症领域开展传统的前瞻性研究仍受到众多限制。孟德尔随机化(MR)分析作为一种新兴的研究方法,借助遗传变异为工具变量提供因果的证据,有望在危重症疾病中提供线索。本文从MR分析的原理、MR分析与随机对照试验(RCT)的区别、MR分析在重症领域的运用和可能运用的方法4个方面,系统阐述关于MR分析在重症医学领域应用的研究进展,旨在为该领域研究提供可能的方向。

The condition of critically ill patients changes rapidly,involving pathological changes in multiple systems and organs throughout the body.Exploring the causal relationship of mechanisms can further reveal etiology,treatment,and prognosis of diseases.However,traditional prospective studies in the field of critical care are still subject to numerous limitations.As an emerging research method,Mendelian randomization(MR)analysis uses genetic variation to provide causal evidence for instrumental variables,which is expected to provide clues in critical diseases.This article systematically describes the research progresson the application of MR analysis in critical care medicine from four aspects:the principle of MR analysis,the difference between MR analysis and randomized controlled trial(RCT),the use of MR analysis in the field of critical illness,and the possible methods of application,aiming to provide possible directions for the research in this field.