APOE、SLCO1B1基因多态性与老年2型糖尿病认知功能障碍的相关研究进展

Research progress of APOE and SLCO1B1 polymorphism and cognitive impairment in elderly patients with type 2 diabetes mellitus

老年人2型糖尿病和认知功能障碍是复杂且高发的疾病。有证据表明,认知功能障碍是2型糖尿病的一种内在表型,尤其在老年人群中。2型糖尿病与注意力、工作记忆和面孔记忆之间存在显著的遗传相关性,这表明2型糖尿病与这些认知领域之间存在基因重叠。临床指南也强调了轻度认知障碍在老年2型糖尿病患者管理中的重要性。在精准医疗时代,基因组学可以为研究和治疗疾病提供有效的方法,特别是在优化药物疗效、减少不良反应方面。本文主要围绕APOE、SLCO1B1基因多态性对老年2型糖尿病认知功能障碍的影响进行阐述,并对该领域的未来研究方向进行了探讨。

Type 2 diabetes and cognitive dysfunction are complex and pervasive disorders. There is evidence that cognitive impairment is a possible endophenotype of type 2 diabetes, especially in older populations, where there is a significant genetic correlation between type 2 diabetes and attention, working memory, and face memory, suggesting genetic overlap between type 2 diabetes and these cognitive domains. Clinical guidelines also emphasize the importance of mild cognitive impairment in the management of older patients with type 2 diabetes.In the era of personalized medicine, genomics can provide effective method for research and treatment of diseases, especially in terms of optimal efficacy and reduce adverse reaction, this article mainly around the APOE and SLCO1B1 polymorphism in elderly type 2 diabetes to discuss the influence of cognitive dysfunction, and the future research direction in the field are discussed in this paper.