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表观遗传修饰阅读器MORC3的分子结构及其在疾病发生发展中的作用

Molecular Structure of Epigenetics Reader Morc3 and Its Role in Disease Development
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摘要 MORC3(MORC family CW-type zinc finger 3)是MORC核蛋白超家族中的重要成员,是一种遗传调节因子,常与自身免疫性疾病和癌症的发生发展有关。近年来,随着分子研究技术的快速发展,针对MORC3分子结构的研究也成为了热点。其中,MORC3的锌指结构和ATP酶结构域备受关注,其免疫调节作用也已被发现,且越来越多的研究表明MORC3在人体内起着多元且不可替代的作用。文章主要叙述了MORC3的分子结构和功能及其调控遗传物质和参与疾病发生发展的作用。 MORC3 is an important member of the MORC nuclear protein superfamily.It is a genetic regulatory factor,which is often related to the occurrence of autoimmune diseases and cancer.In recent years,with the rapid development of molecular research technology,researches on the MORC3 molecular structure has also become a hot spot.Among them,the zinc finger structure and the ATP enzyme domain of MORC3 have attracted wide attention,and its immune regulatory effect has also been discovered.In addition,more and more studies have shown that MORC3 plays a diverse and irreplaceable role in the human body.This article mainly introduces the molecular structure and function of MORC3 and its role in regulation of genetic materials,and its participation in the development of diseases.
作者 傅文轩 史彦 FU Wenxuan;SHI Yan(School of Stomatology,Jiangxi Medical College,Nanchang University,Nanchang,330006,China;Department of Endodontics,Affiliated Stomatology Hospital of Nanchang University,Jiangxi Provincial Key Laboratory of Stomatology and Biomedicine,Jiangxi Clinical Research Center for Stomatology,Nanchang,330006,China)
出处 《医学分子生物学杂志》 CAS 2023年第6期540-546,共7页 Journal of Medical Molecular Biology
关键词 MORC3 CW结构域 ATP酶结构域 癌症 抗病毒 MORC3 CW domain ATP enzyme domain cancer antiviral
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