幽门螺杆菌感染与结直肠肿瘤相关性研究进展

Research progress on the relationship between Helicobacter pylori infection and Colorectal tumor

幽门螺杆菌(H.pylori)定植于胃黏膜,可诱导炎性反应并改变胃内微生物群,进而导致一系列胃部疾病,幽门螺杆菌也被确认为胃癌的感染性病因,另外,越来越多的研究表明,幽门螺杆菌慢性感染可能与不同的胃外疾病有关,包括结直肠肿瘤。文章对幽门螺杆菌感染与结直肠癌和腺瘤的关系的进行综述,为临床诊治及早期预防结直肠肿瘤提供参考。

It is well known that Helicobacter pylori(H.pylori)colonizes the gastric mucosa and induces inflammation and alters the gastric microbiota,which in turn leads to cause a range of gastric disorders.Since the identification of H.pylori as an infectious cause of gastric cancer,an increasing number of studies have shown that chronic H.pylori infection may be associated with different extragastric diseases,including colorectal neoplasms.Further investigation of the relationship between H.pylori infection and colorectal cancer and adenoma may provide a reference for clinical diagnosis and treatment and early prevention of colorectal neoplasms.