冠心病与骨质疏松症共病的机制与治疗进展

Mechanism and treatment progress of coronary heart disease and osteoporosis

冠心病与骨质疏松症是2种常见的老年疾病,目前有研究证实两者可能存在因果关系。2种疾病具有共同危险因素及分子调控机制,可能与骨-血管轴钙化异象、脂质氧化物、炎症因子、雌激素、维生素D、维生素K、肠道菌群等多种因素改变有关。因此,监测和预防两者的共危因素,抑制骨-血管轴钙化异象过程,在冠心病和骨质疏松症的预防和治疗过程中具有积极意义。

Coronary heart disease and osteoporosis are two common diseases in the elderly.At present,some studies have confirmed that there may be a causal relationship between them,which can be predictors of each other.The two diseases have common risk factors and molecular mechanism,which may be related to the bone-vascular axis calcification paradox.There are also some other factors,such as lipid oxides,inflammatory factors,estrogen,vitamin D,vitamin K and intestinal flora.Therefore,it is significant to prevent the coronary heart disease and osteoporosis by monitoring the co-risk factors and inhibiting the abnormal process of bone vascular axis calcification.