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血清乳酸脱氢酶、B型钠尿肽与子痫前期及妊娠结局的相关性研究

Relationship between serum lactate dehydrogenase, Type B natriuretic peptide and preeclampsia and pregnancyoutcome
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摘要 目的探讨血清乳酸脱氢酶(LDH)、B型钠尿肽(BNP)水平与子痫前期(PE)及妊娠结局的关系,并分析其预测价值。方法选择80例妊娠早期孕妇,按照有无出现子痫前期分为轻度PE组(n=42)和重度PE组(n=38),另外选择同一期间来院孕检的40例健康早期妊娠孕妇为对照组,所有孕妇均随访至分娩,检测三组血清BNP、LDH水平,统计妊娠结局情况;采用Logistic回归分析探讨血清LDH、BNP和不良妊娠结局的关系。结果轻度PE组、重度PE组血清LDH、BNP水平均高于对照组(P<0.05);重度PE组血清LDH、BNP水平均高于轻度PE组(P<0.05);Logistic回归分析结果显示:血清LDH、BNP水平和不良妊娠结局的关系密切,是PE患者不良妊娠结局的独立预测因子(P<0.05)。结论血清LDH、BNP水平能够为临床医师评估PE患者病情进展提供有效的参考依据,且和不良妊娠结局存在密切联系,是PE患者不良妊娠结局的独立预测因子,具备较高的预测价值,值得临床推广与应用。 Objective To investigate the relationship between serum lactate dehydrogenase(LDH)and B-type natriuretic peptide(BNP)levels and preeclampsia(PE)and pregnancy outcome,and to analyze their predictive value.Methods A total of 80 pregnant women in early pregnancy were selected and divided into mild PE group(n=42)and severe PE group(n=38)according to the presence or absence of preeclampsia.In addition,40 healthy pregnant women in early pregnancy who came to the hospital during the same period were selected as the control group.All pregnant women were followed up until delivery,serum BNP and LDH levels of the three groups were detected,and pregnancy outcomes were statistically analyzed.Logistic regression analysis was used to investigate the relationship between serum LDH,BNP and adverse pregnancy outcomes.Results The levels of serum LDH and BNP in mild PE group and severe PE group were higher than those in control group(P<0.05).Serum LDH and BNP levels in severe PE group were higher than those in mild PE group(P<0.05).Logistic regression analysis showed that serum LDH and BNP levels were closely related to adverse pregnancy outcomes,and were independent predictors of adverse pregnancy outcomes in PE patients(P<0.05).Conclusion Serum LDH and BNP levels can provide an effective reference for clinicians to evaluate the progression of PE patients,and are closely related to adverse pregnancy outcomes.They are independent predictors of adverse pregnancy outcomes in PE patients,and have high predictive value,worthy of clinical promotion and application.
作者 张晨 褚晓幸 谢琴 Zhang Chen;Chu Xiaoxing;Xie Qin(Department of Obstetrics,the Second Affiliated Hospital of Guilin Medical College,Guilin 541000,China)
出处 《实用妇科内分泌电子杂志》 2023年第18期1-3,18,共4页 Electronic Journal of Practical Gynecological Endocrinology
基金 2021年广西医疗卫生重点培育学科建设项目(桂卫科教发[2022]4号) 广西壮族自治区卫生健康委员会自筹经费科研课题(编号Z20201025)。
关键词 血清乳酸脱氢酶 B型钠尿肽 子痫前期 病情进展 妊娠结局 预测价值 Serum lactate dehydrogenase Type B natriuretic peptide Preeclampsia Disease progression Pregnancy outcome Predictive value
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