早期乳腺癌超声造影定性及定量指标的对比研究

Comparative study of qualitative and quantitative indicators of contrast-enhanced ultrasound in early breast cancer

目的将乳腺良性病灶及进展期乳腺癌作为对照对比研究早期乳腺癌超声造影(CEUS)定性及定量指标特征。方法回顾性分析2018年12月至2020年2月经病理诊断的乳腺良、恶性病灶共110例患者资料,均行乳腺CEUS检查并于同期行手术治疗,根据病灶大小及病理提示将病例分为三组,良性乳腺病灶50例(A组)、早期乳腺癌21例(B组)、进展期乳腺癌39例(C组),采用统计软件SPSS 26.0进行统计处理,定性指标的相互比较采用卡方检验;定量指标相互比较采用非参数检验。P<0.05为差异有统计学意义。结果早期乳腺癌与乳腺良性病灶定性及定量指标比较,早期乳腺癌多表现为快进快/慢退的高增强为主且灌注后范围扩大明显,峰值强度高、达峰时间短,两者比较差异有统计学意义(P<0.05);与进展期乳腺癌比较,早期乳腺癌以高增强及等增强更多见,造影剂分布均匀,灌注缺损少见,峰值强度略低于进展期乳腺癌,达峰时间略长,两者比较差异具有统计学意义(P<0.05)。结论早期乳腺癌超声造影定性及定量指标具有一定的特征性,能够为早期乳腺癌的准确诊断提供参考价值及帮助。

Objective The qualitative and quantitative characteristics of contrast-enhanced ultrasound (CEUS) for early breast cancer were compared between benign breast lesions and advanced breast cancer.MethodA retrospective analysis was performed on the data of 110 patients with benign and malignant breast lesions diagnosed pathologically from December 2018 to February 2020, all of whom underwent breast CEUS examination and surgical treatment during the same period. The patients were grouped according to the size of the lesions and pathological indications: The cases were divided into three groups: 50 cases of benign breast lesions (group A), 21 cases of early breast cancer (group B), and 39 cases of advanced breast cancer (group C). Statistical software SPSS 26.0 was used for statistical processing, and χ^(2) test was used for comparison of qualitative indicators. The quantitative indicators were compared with each other by Nonparametric test. P<0.05 was considered statistically significant.Results Comparison of qualitative and quantitative indicators between early breast cancer and benign breast lesions showed that early breast cancer was mainly characterized by high enhancement of fast advance/slow regression, and the scope expanded significantly after perfusion, with high peak intensity and short peak time, and the difference was statistically significant (P<0.05). Compared with advanced breast cancer, high enhancement and isoenhancement were more common in early breast cancer, contrast agent distribution was uniform, perfusion defect was rare, peak intensity was slightly lower than that of advanced breast cancer, and peak time was slightly longer, the difference between the two was statistically significant (P<0.05).Conclusion The qualitative and quantitative indicators of contrast-enhanced ultrasound have certain characteristics, which can provide reference value and help for the accurate diagnosis of early breast cancer.