肥胖对胃癌患者手术治疗效果的影响研究

Effect of obesity on surgical treatment of gastric cancer patients

目的研究肥胖对胃癌患者手术治疗效果的影响。方法回顾性分析2018年5月至2023年6月132例行腹腔镜胃癌根治术患者的临床资料,根据体重指数(BMI)是否≥25.0 kg/m^(2)分为肥胖组(n=45例)和非肥胖组(n=87例)。用SPSS 20.0软件进行数据处理,围手术期各项指标等计量资料采用(x±s)表示,行独立样本t检验;术后并发症等计数资料采用χ^(2)检验进行比较。P<0.05表示差异有统计学意义。结果与非肥胖组患者相比,肥胖组患者的手术时长、术后住院天数和肛门排气时间明显较长,术中出血量明显较多,而淋巴结清扫数目明显较少,术后并发症的发生率明显高于非肥胖组患者(23.7%vs.7.8%),差异均有统计学意义(P<0.05)。手术前后肥胖组患者的白细胞胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)和C反应蛋白(CRP)表达量均明显高于非肥胖组,差异有统计学意义(P<0.05)。结论肥胖可能是引起胃癌患者手术疗效下降的影响因素之一,值得临床上提高重视程度。

Objective To study the effect of obesity on surgical treatment of gastric cancer patients.Methods Clinical data of 132 patients undergoing laparoscopic radical gastrectomy from May 2018 to June 2023 were retrospectively analyzed. According to body mass index(BMI)≥25.0 kg/m^(2),they were divided into obese group (n=45 cases)and non-obese group(n=87 cases). SPSS 20.0 software was used for data processing. Measurement data such as perioperative indicators were expressed by(x±s),and independent sample t test was performed. The statistical data of postoperative complications were compared by χ^(2) test. P < 0.05 indicated that the difference was statistically significant.Results Compared with the non-obese group,the operation duration,postoperative hospitalization days and anal exhaust time in the obese group were significantly longer,the amount of intraoperative blood loss was significantly more,the number of lymph nodes dissection was significantly less,and the incidence of postoperative complications was significantly higher than that in the non-obese group(23.7% vs. 7.8%),with statistical significance (P < 0.05). The expression levels of interleukin-6(IL-6),tumor necrosis factor α(TNF-α)and C-reactive protein(CRP)in obese group were significantly higher than those in non-obese group before and after operation,with statistical significance (P < 0.05).Conclusion Obesity may be one of the influencing factors leading to a decrease in surgical efficacy in gastric cancer patients,and it is worthy of increasing clinical attention.