膝三针电针联合穴位贴敷治疗膝骨关节炎的疗效及对炎症因子影响

Therapeutic Effects of Knee Three Needle Electroacupuncture Combined with Skin Patch on Acupoints on Knee Osteoarthritis and Its Impact on Inflammatory Factors

目的:探讨膝三针电针结合穴位贴敷治疗膝骨关节炎(KOA)的临床疗效以及对血清中炎症因子的影响。方法:纳入广西中医药大学附属瑞康医院就诊的60例KOA患者,随机分为治疗组及对照组,每组30例。对照组给予口服艾瑞昔布片治疗,治疗组给予膝三针电针结合穴位贴敷治疗,两组均连续治疗3周。3周后对比两组的VAS评分、WOMAC评分、总有效率及血清中细胞因子IL-6、TNF-α、IL-1β水平的变化情况,随后进行评价。结果:两组治疗后VAS疼痛评分、WOMAC总评分比治疗前下降(P<0.05),且治疗组下降优于对照组,两者之间差异具有统计学意义(P<0.05);两组经过治疗后血清中的IL-6、TNF-α、IL-1β水平较治疗前均下降,且治疗组优于对照组;治疗组的总有效率是90.00%(27/30),对照组为73.33%(22/30),差异具有统计学意义(P<0.05)。结论:膝三针电针联合穴位贴敷组与艾瑞昔布片组均可改善KOA患者的膝关节活动障碍,减轻膝关节疼痛,以及下调血清中的炎性因子。膝三针电针联合穴位贴敷的临床疗效较艾瑞昔布片明显,可有效提高患者生活质量,有助于延缓KOA病情进展,其疗效机制与血清中IL-6、TNF-α、IL-1β水平下降有关。

Objective:To explore the clinical effects of knee three needle electroacupuncture combined with skin patch on acupoints(KTNECSPA)on knee osteoarthritis(KOA)and its impact on inflammatory factors in the serum.Methods:60 patients with knee osteoarthritis were recruited in this study from Ruikang Hospital,Guangxi University of Chinese Medicine and randomly divided into treatment group and control group,with 30 cases in each group.The control group was treated with oral imrecoxib tablets,and the treatment group was treated with KTNECSPA.Both groups were treated for 3 weeks.After the treatment,the VAS score,WOMAC score,total effective rate and the change of serum levels of cytokines IL-6,TNF-αand IL-1β in the two groups were compared,and evaluated.Results:(1)VAS pain score and WOMAC total score decreased compared with those before the treatment(P<0.05).The decrease in the treatment group was more apparent than that in the control group and the difference was statistically significant(P<0.05).(2)The levels of cytokines IL-6,TNF-αand IL-1βin serum of both groups decreased after the treatment,and the treatment group was more apparent.(3)The total effective rate was 90.00%(27/30)in the treatment group and 73.33%(22/30)in the control group,and the difference was statistically significant(P<0.05).Conclusion:Both KTNECSPA group and the imrecoxib tablet group can improve knee joint movement disorder of KOA patients,reduce knee joint pain,and down-regulate the inflammatory factors in serum.The clinical effect of KTNECSPA group is more obvious than that of imrecoxib tablet group.KTNECSPA can effectively enhance the quality of patients’lives,and help slow the progression of knee osteoarthritis.Its therapeutic mechanism is related to the decline of serum levels of IL-6,TNF-αand IL-1β.