冠心病伴发抑郁影响因素的meta分析

Influencing factors of coronary heart disease accompanied by depression:a meta-analysis

目的:分析冠心病伴发抑郁(CHDD)的影响因素。方法:计算机检索PubMed、EMbase、Cochrane Library、Wan Fang、VIP、CNKI、CBM数据库中关于CHDD影响因素的文献,检索时限从建库至2022年10月,应用Stata 16.0软件进行meta分析。结果:共纳入18篇文献,总样本量91 930例。meta分析结果显示,性别、病程、心功能、文化程度、医保来源、婚姻情况、家庭支持、性格为CHDD的影响因素,其OR(95%CI)分别为1.34(1.29,1.40)、2.49(1.30,4.77)、1.85(1.14,3.00)、1.11(1.06,1.15)、1.64(1.33,2.03)、1.49(1.36,1.63)、1.38(1.05,1.80)、1.63(1.04,2.57),差异均有统计学意义(P<0.05)。结论:CHDD影响因素较多,应制定针对性的防治措施,积极关注CHDD患者心理状况,以降低不良心血管事件发生风险。

Objective:To analyze the influencing factors of coronary heart disease accompanied by depression(CHDD).Methods:Literatures on the influencing factors of CHDD in PubMed,EMbase,Cochrane Library,Wan Fang,VIP,CNKI,and CBM databases were searched by computer.The search time limit was from the establishment of databases to October 2022.A meta-analysis was performed using Stata 16.0 software.Results:A total of 18 articles were included with a total sample size of 91,930 cases.Meta-analysis results showed that gender,course of disease,heart function,education level,medical insurance source,marital status,family support,and personality were the influencing factors of CHDD with OR(95% CI) of 1.34(1.29,1.40),2.49(1.30,4.77),1.85(1.14,3.00),1.11(1.06,1.15),1.64(1.33,2.03),1.49(1.36,1.63),1.38(1.05,1.80) and 1.63(1.04,2.57),respectively,and the differences were statistically significant( all P<0.05).Conclusion:There are many influencing factors of CHDD.Therefore,targeted prevention and treatment measures should be developed,and the psychological status of CHDD patients should be actively paid attention to in order to reduce the risk of adverse cardiovascular events.