溶杆菌中活性天然产物的研究进展

Research Progress in Bioactive Natural Products from Lysobacter

微生物次级代谢产物是天然药物的重要来源,广泛应用于医药和农业生产。放线菌和真菌是产生抗生素的主要微生物,但经过长期大量的筛选,从中发现新抗生素越来越困难。随着基因测序技术的进步,越来越多的微生物基因组被测序,许多以前被忽视的微生物发现也具有产生新抗生素的潜力。溶杆菌是新型生防细菌,对植物病原真菌、细菌、卵菌和线虫等具有拮抗作用,从溶杆菌中已经发现大量结构新颖和活性显著的次级代谢产物,在生防制剂和前体药物方面具有应用前景。本文对溶杆菌资源分布、次级代谢产物种类和应用进行综述,希望为进一步从环境中筛选分离溶杆菌和发现更多具有新颖活性的天然产物提供参考。

Microbial secondary metabolites are an important source of natural drugs and are widely used in medical and agricultural production.Actinomycetes and fungi are the main microorganisms that produce antibiotics,but it is becoming increasingly difficult to discover new antibiotics from them after a long and extensive screening.With advances in sequencing technology,more and more microbial genomes are being sequenced,and it has been found that many previously neglected microbes also have the potential to produce new antibiotics.The genus Lysobacter have antagonistic activities against a range of plant pathogenic fungi,bacteria,oomycetes,and nematodes,and several secondary metabolites with novel structures and significant biological activities have been identified from Lysobacter,which have potential applications in biocontrol agents and promising drug leads.In this paper,we review the distribution of Lysobacter resources and their secondary metabolites,aiming to provide a reference for further screening of Lysobacter from the environment and discovering more bioactive natural products.