肺癌抗体偶联药物研究进展

Antibody-drug conjugates in lung cancer:Current research status,challenges and prospects

抗体偶联药物(antibody-drug conjugates,ADC)兼有传统化疗药物的强大杀伤作用和抗体药物的精确靶向性,为解决肺癌治疗困境带来新的希望。概述了ADC的作用机制,介绍了ADC药物在肺癌中的临床研究进展,分析了ADC在肺癌中应用的挑战,展望了ADC在肺癌中的发展方向和应用前景。

Antibody-drug conjugates(ADC)drugs have both the powerful killing effect of traditional chemotherapy drugs and the precise targeting of antibody drugs,bringing new hope for solving the dilemma of lung cancer treatment.This review article summarized the mechanism of action of antibody-drug conjugates(ADC),introduced the clinical research progress of ADC in lung cancer,analyzed the challenges of ADC application in lung cancer,and looked forward to the development direction and application prospects of ADC in lung cancer.