成人非心脏手术患者复苏室谵妄与术后谵妄发病风险的相关性研究:基于观察性研究的Meta分析

Association between post⁃anesthesia care unit delirium and postoperative delirium after noncardiac surgeries in adults:A meta⁃analysis based on observational studies

目的:采用Meta分析的方法研究复苏室谵妄(PACU-D)和术后谵妄(POD)两者之间的关系。方法:本研究综合检索Embase、PubMed、Ovid、Cochrane Library和常用中文数据库,纳入了报道PACU-D和病房POD发生率的观察性研究,使用R语言对提取的数据进行统计分析,旨在确定非心脏手术成人患者全身麻醉后PACU-D与POD发生率之间的关系。结果:本研究共纳入7篇观察性研究(3357例),合并后两者相关的OR=3.14(95%CI:2.15~4.57),其中异质性I2检验提示异质性为41%,中等效应水平。结论:本Meta分析发现,PACU-D与POD发病率呈正相关,PACU-D是POD的危险因素。

Objective:To study the relationship between post-anesthesia care unit delirium(PACU-D)and postoperative delirium(POD)after noncardiac surgeries under general anesthesia by Meta-analysis.Methods:By searching the databases including Embase,PubMed,Ovid,Cochrane Library,and sev-eral Chinese on-line literature platforms,observational studies that reported the incidence of adult PA-CU-D and POD in the ward were enrolled.Review Manager 5.4 was used to analyze the extracted da-ta and the relationship between the incidences of PACU-D and POD.Results:Seven observational studies involving 3357 adult patients were enrolled in this study,and the pooled OR was 3.14(95%CI:2.15-4.57),with an I2 statistically showing a moderate level of heterogeneity of effect sizes of 41%.Conclusion:Based on this meta-analysis,there is a positive association between PACU-D and POD.