动脉栓塞药物洗脱微球的研究进展

Research progress in drug-eluting beads used for transarterial chemoembolization

药物洗脱微球经动脉化疗栓塞术(drug-eluting beads transarterial chemoembolization,DEBTACE)是目前治疗不可切除肝恶性肿瘤的常用方法之一,通过动脉内注射药物洗脱微球达到栓塞肿瘤供血动脉和杀伤肿瘤细胞的作用。本文系统地阐述用于经动脉化疗栓塞术的不可生物降解和可生物降解药物洗脱微球的最新进展,讨论不同药物的载药能力和载药方式,如细胞毒性药物和具有不同理化性质的抗血管生成药物等,并对药物在体外或体内的释放动力学以及在靶组织和非靶组织中的分布进行详细的介绍。

Drug-eluting beads transarterial chemoembolization(DEB-TACE)is one of the commonly used methods for unresectable hepatic malignancy.Through intra-arterial injection of drug-eluting microspheres DEB-TACE plays the role of blocking the tumor-feeding arteries and killing tumor cells.This paper systematically illustrates the recent advances in the drug-eluting microspheres,including non-biodegradable and biodegradable,used for TACE,and makes a deep discussion on the loading capacity and loading mode of different drugs,focusing on the cytotoxic drugs and the antiangiogenic drugs with different physical and chemical properties,the release kinetics of these drugs in vitro or in vivo,and their distribution in target and non-target tissues.