摘要
通过羟基保护、酯水解、磺酸化、去磺酸酯等反应制备一种17位去乙酰氧基的长春新碱衍生物。采用MTT法对长春新碱及其衍生物进行细胞毒性研究,结果表明17位去乙酰氧基的长春新碱衍生物的细胞毒性小于长春新碱,而且部分抗肿瘤活性优于长春新碱。
A 17-deacetoxy vincristine derivative was prepared by hydroxyl protection,ester hydrolysis,sulfonation,and desulfonation.The cytotoxicity of vincristine derivatives was studied by MTT method.The results showed that the cytotoxicity of vincristine derivatives with 17-deacetoxy group was less than that of vincristine,and some anti-tumor activities were better than that of vincristine.
作者
王国财
彭万才
唐顺之
袁诚
李继荣
牟肖男
许文东
Wang Guocai;Peng Wancai;Tang Shunzhi;Yuan Cheng;Li Jirong;Mu Xiaonan;Xu Wendong(Guangzhou Hanfang Pharmaceutical Co.,Ltd.,National Engineering Research Center of Pharmaceutical Processing Technology of Traditional Chinese Medicine and Drug Innovation,Guangdong Provincial Key Laboratory of Medicinal Lipid,Guangzhou 510006,China)
出处
《广东化工》
CAS
2023年第19期1-3,6,共4页
Guangdong Chemical Industry
基金
广东省科技计划项目(2020B1212070024)。
关键词
长春新碱
衍生物
制备
细胞毒性
抗肿瘤活性
vincristine
derivative
preparation
cytotoxicity
antitumor activity
