一种多维度温和去屑组合物功效评价

Efficacy Evaluation of a Multi-dimensional Mild Anti-dandruff Composition

以吡罗克酮乙醇胺盐、植物提取物、调理剂协同复配制得一种多维度温和去屑的组合物。对其抑制马拉色菌、控油、抗氧化、抗炎舒缓和保湿能力以及温和性进行评价;以Ⅰ型5α-还原酶(SRD5A)、Ⅱ型5α-还原酶(SRD5A2)及透明质酸酶作为生物靶点,对组合物中多种化合物进行分子对接及分子动力学研究。结果表明,该去屑组合物温和性好,能有效抑制马拉色菌,抑菌范围是同等含量吡罗克酮乙醇胺盐的4倍,对5α还原酶和透明质酸酶具有良好的抑制作用,还具有优异的抗氧化和保湿作用,可以从多维度抑制头皮屑的产生。

A multi-dimensional mild dandruff-removing composition is prepared synergistically with piroctone olamine,plant extracts and conditioning agents.Inhibition of Malassezia,oil control,antioxidant,anti-inflammatory,soothing and moisturizing ability and gentleness were evaluated;Type I 5α-reductase(SRD5A),type II 5α-reductase(SRD5A2)and hyaluronidase were used as biological targets to study the molecular docking and molecular dynamics of various compounds in the composition.The results showed that the anti-dandruff composition had good gentleness,could effectively inhibit Malassezia,The bacteriostatic range was 4 times that of the equivalent amount of piroctone olamine,had good inhibitory effect on 5αreductase and hyaluronidase,and had excellent antioxidant and moisturizing effects,which could inhibit dandruff from multiple dimensions.