血清脂联素、瘦素、鸢尾素与男性T2DM患者视网膜病变的关系

The Relationship between Serum Levels of Adiponectin,Leptin and Irisin and Retinopathy in Male Patients with T2DM

目的探讨血清脂联素、瘦素、鸢尾素三种脂肪因子与男性2型糖尿病视网膜病变(DR)的关系以及诊断价值。方法选择2020年10月—2021年10月在青岛大学附属医院住院的224例2型糖尿病(T2DM)男性患者作为研究对象,根据有无DR分为观察组和对照组,根据有无增殖性分为非增殖性DR(NPDR)和增殖性DR(PDR)亚组,检测并收集患者的血清脂联素、瘦素、鸢尾素及临床相关资料,进行相关统计分析。结果观察组血清脂联素、鸢尾素水平显著低于对照组,血清瘦素水平高于对照组,差异有统计学意义(P<0.05);多因素Logistics回归分析结果显示,血清鸢尾素(OR=0.977,95%CI=0.964~0.994)、瘦素(OR=1.827,95%CI=1.409~2.372)、脂联素(OR=0.755,95%CI=0.668~0.856)是DR发生的风险因素;ROC曲线显示,血清鸢尾素、脂联素和瘦素联合对DR(AUC=0.85)和PDR(AUC=0.82)具有较高的诊断价值。结论血清脂联素、瘦素、鸢尾素与男性DR的发生和病情程度有关,对于DR的预防和病情评估具有一定的价值。

Objective To investigate the association of three adipokines,serum adiponectin,leptin and irisin,with type 2 diabetic retinopathy(DR)in male and their diagnostic efficacy.Methods Total of 224 male patients with type 2 diabetes mellitus(T2DM)selected from the Affiliated Hospital of Qingdao University,from October 2020 to October 2021 were included and divided into observation and control groups according to the presence or absence of DR changes,and into nonvalue-added DR(NPDR)and value-added DR(PDR)subgroups according to the presence or absence of value-addedness,and serum lipocalin,leptin,irisin and clinically relevant data were tested and collected from the patients for relevant statistical analysis.Results There were significant diff erences between serum adiponectin,leptin and irisin in the observation group and the control group;the results of multifactorial Logistic regression analysis showed that serum irisin(OR=0.977,95%CI=0.964~0.994),leptin(OR=1.827,95%CI=1.409~2.372),and adiponectin(OR=0.755,95%CI=0.668~0.856)were risk factors for the development of DR;ROC curves showed that the combination of serum irisin,adiponectin and leptin had a high diagnostic value for DR(AUC=0.85)and PDR(AUC=0.82).Conclusion Serum adiponectin,leptin,and irisin are associated with the occurrence and extent of male DR,and are of value for the prevention and assessment of DR.