ω-3脂肪酸对首发精神分裂症急性期疗效的研究

ω-A Study on the Efficacy of 3 Fatty Acids in the Acute Phase of First-Episode Schizophrenia

目的本研究旨在探讨服用深海鱼油补充ω-3脂肪酸对首发精神分裂症急性期患者改善精神病性症状与减轻代谢综合征发生风险的关系。方法选取2021年9月—2022年9月淄博市精神卫生中心收治的符合ICD-10精神分裂症诊断标准并且服用抗精神病药物的54例患者,按照随机数表法分为鱼油组(30例)和安慰剂组(24例)。在治疗前及治疗后第4、8、12周对两组患者进行阳性与阴性症状量表(Positiveand Negative Syndrome Scale,PANSS)、外显攻击行为量表(Modified Overt Aggression Scale,MOAS)、简明精神病评定量表(Brief Psychiatric Rating Scale,BPRS)评估,同时应用精神分裂症认知功能成套测验(MATRICS Consensus Cognitice Battery,MCCB)评价两组患者治疗前后的认知功能,并采集患者血液生化指标,记录患者血胆固醇、甘油三酯、高密度脂蛋白(HDL)、低密度脂蛋白(LDL)水平。结果两组患者PANSS、BPRS、MOAS评分在第4周均降低,两组比较,差异无统计学意义(P>0.05);第8、12周鱼油组评分明显低于安慰剂组,差异有统计学意义(P<0.05)。血胆固醇、甘油三酯、LDL在第4周均升高,两组比较,差异无统计学意义(P>0.05);在第8、12周安慰剂组升高幅度低于鱼油组,差异有统计学意义(P<0.05)。HDL在第4周均降低,两组比较,差异无统计学意义(P>0.05);在第8、12周鱼油组降低幅度低于安慰剂组,差异有统计学意义(P<0.05)。干预后,两组患者MCCB评分各项指标均升高,且鱼油组患者MCCB各项评分均高于安慰剂组,差异有统计学意义(P<0.05)。结论每日服用深海鱼油补充ω-3脂肪酸对首发精神分裂症急性期患者的精神症状改善明显,特别是减少冲动攻击行为和改善患者的认知功能,并且能够减轻代谢综合征发生风险。

Objective Objective The purpose of this study is to explore the supplementation of deep-sea fish oilω-The relationship between the improvement of psychiatric symptoms and the reduction of the risk of metabolic syndrome in patients with first-episode schizophrenia in the acute phase of 3 fatty acids.Methods From September 2021 to September 2022,54 patients who met the ICD-10 diagnostic criteria for schizophrenia and took antipsychotic drugs in Zibo Mental Health Center were randomly assigned to fish oil group(n=30)and placebo group(n=24).Before treatment and at the 4th,8th and 12th weeks after treatment,the patients in the two groups were scored with Positive and Negative Syndrome Scale(PANSS),Modified Over Aggression Scale(MOAS)and Brief Psychiatric Rating Scale(BPRS),at the same time,the cognitive function scores of the two groups of patients before and after treatment were evaluated with the schizophrenia cognitive function assessment scale(MCCB),and the blood biochemical indicators of the patients were collected,and the levels of blood cholesterol,triglycerides,High-density lipoprotein(HDL),low-density lipoprotein(LDL)were recorded.Results The results showed that the PANSS,BPRS,and MOAS scores of both groups of patients decreased at week 4,and there was no statistically significant diff erence between the two groups(P>0.05);at weeks 8 and 12,the score of the fish oil group was significantly lower than that of the placebo group,and there was a statistical diff erence between the two groups(P<0.05).Blood cholesterol,triglycerides,and LDL all increased at week 4,and there was no statistically significant diff erence between the two groups(P>0.05);at weeks 8 and 12,the placebo group was higher than the fish oil group,and there was a statistical diff erence between the two groups(P<0.05).HDL decreased at week 4,and there was no statistically significant difference between the two groups(P>0.05);at weeks 8 and 12,the decrease in fish oil group was lower than that in placebo group,and there was a statistical diff erence between the two groups(P<0.05).after the intervention,the related indicators of MCCB scores of patients in both groups increased to varying degrees,and the scores of Working memory,speech learning and problem reasoning dimensions of patients in the fish oil group increased significantly compared with those in the placebo group(P<0.05).Conclusion Take deep-sea fish oil every dayω-3 fatty acids significantly improve the mental symptoms of first-episode schizophrenia patients in the acute phase,especially reducing impulsive and aggressive behavior,improving cognitive function,and reducing the risk of metabolic syndrome.