小柴胡散联合小儿氨酚伪麻片治疗胃肠型感冒的疗效及对血清炎性因子表达的影响

Effect of Xiaochaihu Powder Combined with Paediatric Paracetamol Pseudoephedrine Tablets on Gastrointestinal Cold and the Expression of Serum Inflammatory Factors

目的探讨小柴胡散联合小儿氨酚伪麻片治疗胃肠型感冒的疗效及对血清炎性因子表达情况的影响。方法选择2022年1月—2023年1月在吉林省妇幼保健院诊治的100例胃肠型感冒患儿作为研究对象,根据1:1随机信封抽签原则把100例患儿分为对照组50例、试验组50例,对照组给予小儿氨酚伪麻片治疗,试验组在对照组治疗的基础上给予小柴胡散治疗,两组均治疗观察7 d,比较两组的治疗效果及血清炎性因子表达变化情况。结果治疗后试验组的总有效率显著高于对照组,差异有统计学意义(P<0.05)。试验组的咳嗽、流涕、鼻塞、发热、肺部啰音等症状消失时间显著早于对照组(P<0.05)。试验组治疗期间的头痛头晕、恶心呕吐、全身酸痛、口干等不良反应发生率与对照组比较,差异无统计学意义(P>0.05)。两组治疗后的C-反应蛋白与淋巴细胞计数均显著低于治疗前(P<0.05),治疗后试验组的C-反应蛋白与淋巴细胞计数均显著低于对照组,差异有统计学意义(P<0.05)。治疗后两组的IgG和IgA含量均明显高于治疗前(P<0.05),治疗后试验组的IgG和IgA含量明显高于对照组,差异有统计学意义(P<0.05)。结论小柴胡散联合小儿氨酚伪麻片治疗胃肠型感冒能促进缓解临床症状,提高治疗效果,不会增加不良反应的发生,也能有效抑制炎性因子的表达,增强患儿的免疫功能。

Objective To investigate the effect of Xiaochaihu powder combined with paediatric paracetamol and pseudoephedrine tablets in the treatment of gastrointestinal cold and its influence on the expression of serum inflammatory factors.Methods From January 2022 to January 2023,100 children with gastrointestinal cold who were treated in Jilin Provincial Maternal and Child Health Hospital were selected as the research subjects.Accorded to the principle of 1:1 random envelope drawing,100 children were divided into two groups:the control group(50 cases)and the experimental group(50 cases).The control group were treated with paediatric paracetamol pseudoanesthesia tablets.The experimental group were treated with Xiaochaihu powder on the basis of the treatment of and observed for 7 days,The therapeutic effect and the expression of serum inflammatory factors in the two groups were observed and recorded.Results After treatment,the total eff ective rates of the experimental group were 98.00%,which were significantly higher than that of the control group(84.00%,P<0.05).The disappearance time of cough,runny nose,stuffy nose,fever,lung rale and other symptoms in the experimental group were significantly lower than that in the control group(P<0.05).The incidence rates of adverse reactions such as headache,dizziness,nausea and vomiting,general soreness and dry mouth in the experimental group during the treatment period were 6.00%,and there were no significant diff erence compared with 8.00%in the control group(P>0.05).The C-reactive protein and lymphocyte counts in the two groups after treatment were significantly lower than those before treatment(P<0.05),and the C-reactive protein and lymphocyte counts in the experimental group after treatment were also significantly lower than those in the control group(P<0.05).After treatment,the contents of IgG and IgA in the two groups were significantly higher than those before treatment(P<0.05).After treatment,the contents of IgG and IgA in the experimental group were significantly higher than those in the control group(P<0.05).Conclusion Xiaochaihu powder combined with paediatric paracetamol pseudoephedrine tablets can promote the relief of clinical symptoms,improve the treatment eff ect,and will not increase the occurrence of adverse reactions.It can also eff ectively inhibit the expression of inflammatory factors and improve the immune function of children.