芝麻素酚葡萄糖苷生理活性功能研究进展

Advances in biological activities of sesaminol glucosides

芝麻素酚葡萄糖苷(sesaminol glucosides,SGs)是一种重要的水溶性芝麻木脂素,具有多种生理活性功能和广泛的药理作用,近年来研究者开展了大量的研究。文章聚焦SGs生理活性功能,从抗氧化、抗炎、抗肿瘤、抗新冠病毒、心血管保护、预防肥胖、神经保护和抗皮肤衰老8个方面,梳理总结了最新的研究进展。通过对现有研究分析发现,SGs许多生理功能性研究尚停留在体外细胞模型和动物模型阶段,距离临床应用和产品开发尚有较大差距。借助现代医学和工业生物技术的最新发展成果,进一步推进临床药理机制研究,挖掘新的生理功能,完善产品研究开发将是未来SGs研究方向。

Sesaminol glucosides(SGs),an important lipid-soluble lignan from Sesamum indicum,possess multiple biological activities and a wide range of pharmacological effects.In recent years,extensive research on SGs has been conducted.This paper focuseS on the biological activities of SGs and summarized the latest research advancements in eight aspects,including anti-oxidation,anti-inflammatory,anti-tumor,inhibition of COVID-19,cardiovascular protection,prevention of obesity,neuroprotection,and anti-skin aging.Analysis of the existing studies reveals that much research on the physiological functions of SGs is still at the in vitro cell model or animal model stage and that achieving clinical application and industrial product development is still a long way off.With the latest developments in modern medical technology and industrial biotechnology,promoting research on clinical pharmacology mechanisms,exploring novel physiological functions,and improving product research and development show promise for future SGs research.