胎儿期及儿童早期饥荒暴露与成年期高血压发病风险的Meta分析

Fetal and early childhood famine exposure and adult hypertension risk:a meta-analysis

目的 探讨胎儿期及儿童早期饥荒暴露与成年期高血压发病风险之间的关系,为预防高血压提供理论依据。方法 计算机检索PubMed、Embase、Web of Science、Cochrane Library、知网、维普、万方和CBM数据库,检索时限截至2022年4月,应用Stata 16.0软件进行Meta分析。结果 共纳入19篇文献(横断面研究13篇、队列研究6篇),包括220 687例研究对象。Meta分析结果显示:胎儿期及儿童早期饥荒暴露与成年期高血压发病风险呈正相关(胎儿期:OR=1.28,95%CI:1.15~1.42;儿童早期:OR=1.39,95%CI:1.25~1.54)。亚组分析结果显示,亚洲地区胎儿期及儿童期饥荒暴露与成年期高血压发病风险相关性较其他地区更为显著(胎儿期:OR=1.23,95%CI:1.12~1.35;儿童早期:OR=1.40,95%CI:1.25~1.57)。结论 胎儿期及儿童早期饥荒暴露与成年期高血压发病风险之间存在关联。预防胎儿期及儿童早期营养不良是预防成年期高血压的关键。

Objective To explore the relationship between fetal and early childhood famine exposure and the risk of hypertension in adulthood,provide a theoretical basis for prevention of hypertension.Methods Databases including Pubmed,Embase,Web of Science,Cochrane Library,CNKI,VIP,Wanfang and CBM were searched by computer until April 2022.Stata 16.0 software was used for meta-analysis.Results A total of 19 studies(13 cross-sectional studies and 6 cohort studies) were included,including 220687 subjects.The results of meta-analysis showed that there was a positive correlation between fetal and early childhood famine exposure and the risk of hypertension in adulthood(fetal:OR=1.28,95%CI:1.15~1.42;Early childhood:OR=1.39,95%CI:1.25~1.54).Subgroup analysis showed that fetal and childhood famine exposure was more significantly associated with the risk of hypertension in adulthood in Asia than in other regions(fetal:OR=1.23,95%CI:1.12~1.35;Early childhood:OR=1.40,95%CI:1.25~1.57).Conclusion There is an association between fetal and early childhood famine exposure and the risk of hypertension in adulthood.Prevention of fetal and early childhood malnutrition is the key to preventing hypertension in adulthood.