年龄相关性白内障患者的血清Apelin-13水平及临床意义

Level and clinical significance of serum Apelin-13 in patients with age-related cataract

目的 探讨年龄相关性白内障(ARC)患者的血清Apelin-13水平及临床意义。方法 (1)选取拟手术治疗的100例ARC患者作为观察组,80例健康体检者作为对照组。比较两组的一般资料、血糖、血脂及血清Apelin-13水平。采用多因素Logistic回归模型分析ARC发生的影响因素,并采用受试者工作特征曲线分析血清Apelin-13水平对ARC的诊断价值。(2)根据晶状体出现浑浊的初始部位将观察组患者分为皮质性白内障组(35例)、核性白内障组(33例)、后囊膜下白内障组(32例),比较3组患者血清Apelin-13水平。(3)分析ARC患者血清Apelin-13水平与一般资料、血糖、血脂、眼部参数的相关性。结果 (1)与对照组相比,观察组患者的年龄更大,体质指数、收缩压、空腹血糖水平、血清Apelin-13水平更高,合并高血压病史及糖尿病史的比例更高(P<0.05)。年龄、体质指数、高血压病史、糖尿病史、收缩压、空腹血糖水平、血清Apelin-13水平是ARC发生的影响因素(P<0.05)。血清Apelin-13水平诊断ARC的曲线下面积为0.908,灵敏度为83.0%,特异度为91.2%。(2)3种类型ARC患者血清Apelin-13水平差异具有统计学意义(P<0.05),其中后囊膜下白内障组血清Apelin-13水平相对较高。(3)ARC患者血清Apelin-13水平与年龄、体质指数、收缩压、空腹血糖水平呈正相关(P<0.05)。结论 ARC患者的血清Apelin-13水平升高,其中后囊下白内障患者血清Apelin-13水平相对较高。血清Apelin-13水平升高是ARC发生的危险因素,对ARC有一定的诊断价值。

Objective To explore the level and clinical significance of serum Apelin-13 in patients with age-related cataract(ARC).Methods(1)A total of 100 ARC patients prepared for surgical treatment were selected as observation group,and 80 healthy check-up individuals as control group.The general data,blood glucose,blood lipid,and serum Apelin-13 level were compared between the two groups.The multivariate Logistic regression model was used to analyze the influencing factors for the occurrence of ARC,and diagnostic value of serum Apelin-13 level on ARC was analyzed by employing receiver operating characteristic curve.(2)Patients in the observation group were divided into cortical cataract group(35 cases),nuclear cataract group(33 cases),or posterior subcapsular cataract group(32 cases)according to the initial site where lens appeared cloudy.The serum Apelin-13 level was compared between the three groups.(3)The correlation between serum Apelin-13 level and general data,blood glucose,blood lipid,and eye parameters of ARC patients was analyzed.Results(1)Compared with the control group,the observation group exhibited an older age,and higher body mass index,systolic blood pressure,fasting blood glucose level,serum Apelin-13 level,as well as a higher proportion of concomitant hypertension history and diabetic history(P<0.05).Age,body mass index,hypertension history,diabetic history,systolic blood pressure,fasting blood glucose level,and serum Apelin-13 level were the influencing factors for the occurrence of ARC(P<0.05).The area under the curve of serum Apelin-13 level for diagnosing ARC was 0.908,the sensitivity was 83.0%,and the specificity was 91.2%.(2)There was statistically significant difference in serum Apelin-13 level between ARC patients with 3 types(P<0.05),therein patients in the posterior subcapsular cataract group obtained a relatively high serum Apelin-13 level.(3)Serum Apelin-13 level positively correlated with age,body mass index,systolic blood pressure,and fasting blood glucose level of ARC patients(P<0.05).Conclusion The level of serum Apelin-13 is elevated in patients with ARC,therein serum Apelin-13 level is relatively high in patients with posterior subcapsular cataract.The elevation of serum Apelin-13 level is the risk factor for the occurrence of ARC,exerting diagnostic value on ARC to a certain extent.