趋化因子配体13在常见感染性病原体感染中的表达及意义

Expression and significance of C-X-C motif chemokine ligand 13 in common infectious pathogens infection

趋化因子配体13(C-X-C motif chemokine ligand 13,CXCL13)又称B细胞吸引趋化因子1或B淋巴细胞趋化因子,通过与B细胞、辅助T细胞上的G蛋白偶联趋化因子受体结合,诱导其向生发中心运输,促进B细胞成熟和抗体应答,从而实现对病毒清除以及炎症的快速控制。然而,目前相关研究表明CXCL13水平过高可能导致免疫反应受损,促进疾病进展。CXCL13水平变化可作为反映疾病进展、抗病毒疗效有效指标,并且对疫苗研发有所帮助。因此,本文主要对CXCL13在常见感染性病原体感染如人类免疫缺陷病毒感染、乙型肝炎病毒感染、结核分枝杆菌感染以及SARS-CoV-2感染中的表达及其意义进行综述。

C-X-C motif chemokine ligand 13(CXCI13)can promote B cell maturation and antibody response by binding to G protein-coupled chemokine receptor(CXCR5)that locating on B cells and Tfh cells.Consequently,the inhibition of virus replication,even the elimination of virus,can be realized,which conclusively facilitating to the rapid control of inflammation.However,it should be noted that excessive increase of CXCL13 may lead to impaired immune response and further deterioration of infection.In view of these important effects,the change of CXCL13 concentration is likely to become an effective index for evaluation of disease progression and antiviral efficacy,and will be helpful for future vaccine development.In summary,the paper mainly reviews the expression and significance of CXCL13 in common infectious pathogens such as human immunodeficiency virus,hepatitis B virus infection,tuberculosis and SARS-CoV-2.