慢加急性肝衰竭合并感染的诊断与预后研究进展

Research advances in diagnosis and prognosis of acute-on-chronic liver failure complicating infection

慢加急性肝衰竭(ACLF)是在慢性肝病基础上由各种原因引起的肝细胞大量坏死,导致多器官功能衰竭和短期高致死率的综合征。由于ACLF强烈的全身炎症反应和氧化应激,合并感染后免疫功能进一步紊乱,导致感染早期诊断困难。近年来,随着对ACLF研究的深入及检验技术的发展,临床对ACLF合并感染的诊断能力大大提高。该文综述了目前ACLF合并感染方面的最新实验室诊断方法及预后研究进展,以期能提高其临床诊治水平。

Acute-on-chronic liver failure(ACLF)is a syndrome of multiple organ failure and shortterm high mortality caused by massive hepatocyte necrosis due to various reasons on the basis of chronic liver disease.Due to the strong systemic inflammatory response and oxidative stress in ACLF,the immune function is further compromised after complicating infection,making early diagnosis of infection difficult.In recent years,with the in-depth study of ACLF and the development of laboratory technology,the ability to diagnose ACLF complicating infection has been greatly improved.This paper reviews the research progress in the latest laboratory diagnostic methods and prognosis in the aspect of ACLF complicating infection.