心理、营养综合干预对小细胞肺癌患者人体成分和焦虑抑郁的影响

Effects of comprehensive psychological and nutritional interventions on body composition,anxiety,and depression in small cell lung cancer patients

目的探讨心理、营养综合干预对小细胞肺癌患者人体成分和焦虑抑郁的影响。方法选择潍坊医学院附属医院2021年7月~2022年12月住院化疗的小细胞肺癌患者56例为研究对象,随机分为对照组和研究组。对照组26例应用常规化疗4周期,研究组30例同时应用心理、营养综合干预,两组患者年龄、性别、肿瘤分期相似,具有可比性(P>0.05)。观察化疗4个周期后2周干预前后两组患者肝肾功能、血常规及人体成分和焦虑抑郁的变化。采用抑郁自评量表(SDS)和焦虑自评量表(SAS)进行焦虑抑郁症状自评调查。结果干预前、后两组患者肝肾功能、血常规无明显差异(P>0.05);干预后研究组人体成分各指标有所增加,与对照组比较,差异有统计学意义(P<0.05);干预后研究组SDS和SAS下降,与对照组比较,差异有统计学意义(P<0.01)。结论心理、营养综合干预可缓解小细胞肺癌患者的焦虑和抑郁症状,改善全身营养状况,增加生活指数,有利于化疗顺利实施。

Objective To explore the effects of comprehensive psychological and nutritional interventions on human body composition and levels of anxiety and depression in patients with small cell lung cancer.Methods Fifty-six patients with small cell lung cancer who were hospitalized for chemotherapy in the Affiliated Hospital of Weifang Medical University from July 2021 to December 2022 were selected as the study subjects.They were randomly divided into a control group and a study group.The control group consisted of 26 patients who received 4 cycles of conventional chemotherapy,while the study group consisted of 30 patients who received comprehensive psychological and nutritional interventions.The two groups of patients have similar age,gender,and tumor staging,indicating comparability(P>0.05).This study aims to observe the changes in liver and kidney function,blood routine,body composition,and levels of anxiety and depression in two groups of patients before and after 2 weeks following 4 cycles of chemotherapy.Self Rating Depression Scale(SDS)and Self Rating Anxiety Scale(SAS)were used to conduct a self-evaluation survey of anxiety and depression symptoms.Results There was no significant difference in liver and kidney function,blood routine test between the two groups of patients before and after intervention(P>0.05).After the intervention,the research group showed an increase in various indicators of human body composition,with a statistically significant differences compared to the control group(P<0.05).After the intervention,the SDS and SAS levels in the study group decreased significantly compared to the control group(P<0.01).Conclusion Comprehensive psychological and nutritional interventions can alleviate anxiety and depression symptoms in small cell lung cancer patients,improve overall nutritional status,increase life index,and facilitate the smooth implementation of chemotherapy.