甲状腺乳头状癌容积比与淋巴结转移关系的研究

Tumor volume ratio as a predictive factor for lymph node metastases in thyroid papillary carcinoma in the central area

目的探讨甲状腺乳头状癌的瘤体与甲状腺容积比与淋巴结转移的相关性。方法测量甲状腺瘤体体积与甲状腺容积,分析134例单灶甲状腺乳头状癌患者的容积比及其他临床病理特征与淋巴结转移的相关性。结果淋巴结转移数量与年龄<45岁、侵及包膜有一定的相关性(r<0.300,P<0.05),与性别、瘤体最大径、瘤体体积、容积比均具有弱相关性,其中病理容积比相关性最强(r=0.379,P<0.001)。男性是颈部中央区淋巴结转移的独立危险因素(χ^(2)=13.597P<0.05)。性别与容积比共同预测值AUC=0.760,敏感度=0.574,特异度=0.818。结论相对于瘤体最大径,在甲状腺乳头状癌中容积比可以更好地预测中央区淋巴结转移。

Objective To investigate the correlation between thyroid tumor volume ratio to lymph node metastasis in papillary thyroid carcinoma(PTC).Methods The ratio of thyroid tumors volume to resected thyroid volume was measured by imaging methods before surgery,and the correlation between volume ratio and other clinicopathological features and lymph node metastasis in 134 patients with single focal PTC was analyzed.Results The number of lymph node metastases was associated with age<45 years and invasion of the capsule(r<0.300,P<0.05),and weakly correlated with gender,maximum tumor diameter,tumor volume and volume ratio.Among them,the correlation between patho-volume ratio was strongest(r=0.379,P<0.001).Male genter was an independent risk factor for central cervical lymph node metastasis(χ2=13.597 P<0.05).The co-predictions of sex and volume ratio was AUC=0.760,sensitivity=0.574 and specificity=0.818.Conclusion Compared to the maximum diameter of tumors,the volume ratio in papillary thyroid carcinoma better predicts the metastasis of lymph nodes of papillary thyroid carcinoma in the central region.