揿针疗法联合乳果糖用于癌症疼痛阿片类药物相关性便秘患者的临床疗效及对患者生存质量的影响

Clinical efficacy of press needle therapy combined with lactulose on cancer pain patients with opioid-induced constipation and its impact on the quality of life

目的探讨揿针疗法联合乳果糖治疗癌症疼痛(以下简称“癌痛”)阿片类药物相关性便秘(OIC)患者的效果及对其生存质量的影响,为临床提供参考。方法选取2020年4月至2022年3月广东省第二中医院收治的100例癌痛OIC患者为研究对象,按照随机数字表法分为对照组和研究组,各50例。对照组患者给予乳果糖口服液治疗,研究组患者在对照组基础上结合揿针疗法治疗。比较两组患者整体临床疗效、便秘症状积分、症状严重程度量表(SSS)评分、克利夫兰便秘评分量表(CCS)评分、Bristol大便性质评分及便秘患者生活质量量表(PAC-QOL)评分。结果研究组患者整体临床疗效优于对照组(P<0.05)。两组患者治疗后排便困难、粪便性状及排便不尽感积分低于治疗前,且研究组低于对照组(P<0.05)。两组患者治疗后SSS和CCS评分低于治疗前,且研究组低于对照组(P<0.05)。两组患者治疗后Bristol大便性质评分高于治疗前,且研究组高于对照组(P<0.05)。两组患者治疗后PAC-QOL评分低于治疗前,且研究组低于对照组(P<0.05)。结论揿针疗法联合乳果糖对癌痛OIC患者临床疗效显著,且可改善患者便秘症状及提高生活质量,值得临床应用。

Objective To explore the effect of press needle therapy combined with lactulose on cancer pain patients with opioidinduced constipation(OIC)and its impact on quality of life,so as to provide reference for clinical practice.Methods The 100 cancer pain patients with OIC admitted to the Guangdong Second Traditional Chinese Medicine Hospital from April 2020 to March 2022 were selected as the research subjects,divided into control group and study group by random number table method,with 50 patients in each group.The patients in the control group were treated with lactulose oral liquid,and the patients in the study group were treated with press needle therapy on the basis of the control group.The overall clinical efficacy,constipation symptom score,severity of symptom scale(SSS)score,cleveland constipation scale(CCS)score,Bristol stool quality score,and constipation patient quality of life scale(PAC-QOL)score were compared between two groups.Results The overall clinical efficacy of the study group was better than that of the control group(P<0.05).After treatment,scores of difficulty in defecation,fecal characteristics,incomplete defecation of patients in two groups were lower than before treatment,and study group was lower than control group(P<0.05).After treatment,SSS and CCS scores of patients in two groups were lower than before treatment,and the study group was lower than control group(P<0.05).After treatment,the Bristol stool quality scores of patients in two groups were higher than that before treatment,and the study group was higher than control group(P<0.05).After treatment,PAC-QOL scores of patients in two groups were lower than before treatment,and the scores of patients in the study group was lower than that in the control group(P<0.05).Conclusion The combination of press needle therapy and lactulose has a significant clinical effect on cancer pain patients with OIC,and can improve the symptoms of constipation and improve the quality of life of patients,which is worthy of clinical application.