摘要
Adoptive T-cell therapy(ACT)is a promising therapeutic approach based on the concept of potent T-cell mediated immunity against the tumor.The outcome of antigen-specific T-cells responses relies on the interaction between T-cells and antigen-presenting cells,which provides signals for generating different T-cell phenotypes with different roles in tumor removal.However,such interaction is often not optimal in vivo and results in low therapeutic efficacy.To reach the full potential of the T-cell response,current research put effort into developing dynamic biomaterials as artificial antigen-presenting cells to study and regulate the T-cell activity for controlling T-cell fate.In this perspective,we provide(1)an overview of ACT and general T-cells behaviors,(2)explore the insight on how biomaterials can be used for studying and regulating T-cell behaviors,(3)and discuss conceptual gaps in knowledge for biomaterials-based immunotherapy.
基金
the start-up funding(A0033912)from the Department of Biomedical Engineering
Start-up Fund for RAPs under the Strategic Hiring Scheme(0035876)
the Hong Kong Polytechnic University(University Grant Council),for supporting this work.