宏基因组测序应用于SPF动物的研究进展

Advance in the Application of Metagenomic Sequencing to SPF Animals

SPF动物是无特定病原体动物,在疾病模型、疫苗生产、药理学等多个领域中具有重要作用,借助SPF动物能够更好的解决这些领域所面临的科学问题。微生物在维持机体健康中的重要作用使得其成为研究的热点领域,宏基因组测序作为一种高通量测序技术是促进微生物研究领域发展的有效手段,而SPF动物是研究微生物与机体相互作用的典型模型,为探讨机体与微生物的关系奠定基础。论文就宏基因组测序应用于SPF动物,对肠道微生物多样性、病原体检测、药物作用机制及微生物与健康的关系进行综述,为SPF动物在微生物领域的应用提供参考。

SPF animals are specific pathogen-free animals and play an important role in many fields such as disease models,vaccine production,and pharmacology.Researchers can better solve the scientific problems faced in these fields by using SPF animals.Microorganisms play an important role in maintaining the health of the body,which makes it a hot research field.As a high-throughput sequencing technology,metagenomic sequencing is an effective means to promote the development of microbial research.SPF animals are typical models to study the interaction between microorganisms and the body,which lays the foundation for exploring the relationship between the body and microorganisms.This article reviews the application of metagenomic sequencing in SPF animals to explore intestinal microbial diversity,pathogen detection,drug mechanism and the relationship between microorganisms and health,and provides reference for the follow-up application of SPF animals in the field of microorganisms.