摘要
鸟苷酸结合蛋白(guanylate-binding proteins,GBP)是一类干扰素诱导蛋白,在应对细菌、病毒、衣原体以及寄生虫等病原体感染时,其发挥的作用存在差异,并且影响感染性疾病的发展和结局。目前,研究者发现在细菌等病原体感染引发的细胞自主免疫中,GBP蛋白通过影响炎症小体的经典和非经典活化途径调控细胞焦亡。本文对GBP家族成员结构、进化特征以及炎症小体的经典和非经典活化途径进行了介绍,综述了GBP蛋白调控炎症小体活化的相关研究进展,归纳总结了GBP蛋白影响不同病原体感染的作用机制,以期为感染性疾病的发病机制和诊疗提供新的基础研究线索。
Guanylate-binding proteins(GBPs)are a subfamily of interferon-inducible proteins that undertake distinct roles in the the context of bacteria,virus,chlamydia and parasites infections.These proteins exert a notable influence on the progression and outcomes of infectious diseases.Within the realm of host cell-autonomous immunity against pathogens,GBPs have been identified as the regulators of pyroptosis through canonical and noncanonical inflammasome activation pathways.In this review,we summarize the structure and evolution of GBP family members,the canonical and noncanonical inflammasome activation pathways,the roles of GBPs in regulating inflammasome activation,and the mechanisms of GBPs affecting infections induced by different pathogens.We hope to provide new basic research clues for the pathogenesis and diagnosis and treatment of infectious diseases.
作者
全舒婷
焦伟伟
徐放
孙琳
綦辉
申阿东
Shuting Quan;Weiwei Jiao;Fang Xu;Lin Sun;Hui Qi;Adong Shen(Beijing Key Laboratory of Pediatric Respiratory Infection Diseases,MOE Key Laboratory of Major Diseases in Children,National Key Discipline of Pediatrics,National Clinical Research Center for Respiratory Diseases,Beijing Pediatric Research Institute,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China;Baoding Key Laboratory for Precision Diagnosis and Treatment of Infectious Diseases in Children,Baoding Hospital of Beijing Children’s Hospital,Capital Medical University,Baoding 071000,China;Genetics and Birth Defects Control Center,Beijing Key Laboratory for Genetics of Birth Defects,MOE Key Laboratory of Major Diseases in Children,National Key Discipline of Pediatrics,Beijing Pediatric Research Institute,Beijing Children’s Hospital,Capital Medical University,National Center for Children’s Health,Beijing 100045,China)
出处
《遗传》
CAS
CSCD
北大核心
2023年第11期1007-1017,共11页
Hereditas（Beijing)
基金
国家自然科学基金项目(编号:81871617,81701971,82172280,82100010)
中国科学院病原微生物与免疫学重点实验室开放课题(编号:CASPMI202201)
保定市科技计划(编号:2272P012)
北京市卫生健康委员会高层次公共卫生技术人才培养计划(编号:2022-3-041)资助。
