慢性胃炎病理特征在幽门螺杆菌分型中的价值

Value of pathological features of chronic gastritis for typing of Helicobacter pylori

目的研究慢性胃炎病理特征与Ⅰ型幽门螺杆菌(Ⅰ-Hp)、Ⅱ型幽门螺杆菌(Ⅱ-Hp)的关系及临床应用价值。方法选取胃黏膜活检诊断为慢性胃炎的样本2583例,采用荧光定量PCR法检测Hp并进行分型,分析Ⅰ-Hp、Ⅱ-Hp与慢性胃炎的炎性反应程度、活动度、肠上皮化生及淋巴滤泡形成之间的关系。结果慢性胃炎的炎性反应程度、活动度、肠上皮化生在Ⅰ-Hp、Ⅱ-Hp感染中均存在差异,差异均有统计学意义(P均<0.05)。炎症活动度为Ⅰ-Hp感染的独立危险因素(P<0.05)。结论Ⅰ-Hp和Ⅱ-Hp感染在慢性胃炎炎性反应程度、活动度、肠上皮化生中表现有所差异。活动性炎症提示可能存在Ⅰ-Hp感染。

Objective To assess the relationship between pathological features of chronic gastritis and typeⅠHelicobacter pylori(Ⅰ-Hp)and typeⅡHelicobacter pylori(Ⅱ-Hp)and the value in clinical application.Methods 2583 samples were selected from patients diagnosed with chronic gastritis by gastric mucosal biopsy.Hp was detected and typed by fluorescence quantitative PCR.The relationship betweenⅠ-Hp andⅡ-Hp,and the degree of inflammatory response,activity,intestinal metaplasia and lymphatic follicular formation in chronic gastritis was analyzed.Results There were significant differences in inflammatory response,activity and intestinal metaplasia in chronic gastritis betweenⅠ-Hp andⅡ-Hp infection(all P<0.05).Inflammatory activity was an independent risk factor forⅠ-Hp infection(P<0.05).ConclusionsⅠ-Hp andⅡ-Hp infection have different manifestations in inflammatory response,activity and intestinal metaplasia in chronic gastritis.Active inflammation suggests the potential incidence ofⅠ-Hp infection.