PPARγ和FOXO3a在雌激素受体阳性乳腺癌的表达及临床意义

Expressions and clinical significance of PPARγand FOXO3ain estrogen receptor-positive breast cancer

目的探讨过氧化物酶体增殖物激活受体γ(PPARγ)和叉头框蛋白O3a(FOXO3a)在雌激素受体(ER)阳性乳腺癌组织的表达及临床意义。方法回顾性分析89例女性ER阳性乳腺癌患者的临床资料,采用免疫组化染色法检测ER阳性乳腺癌组织中ER、孕激素受体(PR)、Ki-67、PPARγ和FOXO3a表达,荧光原位杂交法检测人表皮生长因子受体2(HER2)表达,并分析PPARγ和FOXO3a表达与ER阳性乳腺癌患者临床病理特征的关系。结果PPARγ和FOXO3a表达均与淋巴结转移和TNM分期有关(P<0.05),而与患者年龄、病变部位、肿瘤直径、组织学分级以及PR、HER2和Ki-67表达无关(P>0.05)。ER阳性乳腺癌组织中PPARγ与FOXO3a表达呈正相关(rs=0.321,P<0.05)。结论PPARγ、FOXO3a与ER阳性乳腺癌发生、发展有关,有望成为潜在的治疗靶点。

Objective To investigate the expressions and clinical significance of peroxidase proliferator activated receptorγ(PPARγ)and forkhead box O3a(FOXO3a)in estrogen receptor(ER)-positive breast cancer tissues.Methods The clinical data of 89patients with ER-positive breast cancer were retrospectively analyzed.The expressions of ER,progesterone receptor(PR),Ki-67,PPARγand FOXO3ain ER-positive breast cancer tissues were detected by immunohistochemical staining.The expression of human epidermal growth factor receptor 2(HER2)was measured by fluorescence in situ hybridization.The relationship of PPARγand FOXO3aexpressions with the clinicopathological characteristics of the patients with ER-positive breast cancer was analyzed.Results The expressions of PPARγand FOXO3awere closely related to the lymph node metastasis and TNM stage(P<0.05),but were not relevant to the age,position of lesion,diameter of tumor,histological grade and expressions of PR,HER2and Ki-67(P>0.05).The expression of PPARγwas positively correlated with that of FOXO3ain ER-positive breast cancer tissues(rs=0.321,P<0.05).Conclusion PPARγand FOXO3aare closely related with the development and progression of ER-positive breast cancer,and might become the potential therapeutic targets for ER-positive breast cancer.