miRNA作为骨棘球蚴病诊断标志物的研究进展

Research progress in microRNA as a novel diagnostic marker for bone echinococcosis

骨棘球蚴病通常由细粒棘球绦虫和多房棘球绦虫引起,人类在食用被虫卵污染的食物或水时被感染,骨棘球蚴病的治疗一般包括手术和药物治疗,但治疗时间长、费用高,给患者造成了沉重负担。微小RNA(miRNA)已知参与多种生物过程和宿主-寄主相互作用,包括发育、细胞生长和死亡、寿命的相关靶点调节、转录、信号转导和细胞运动,这将有助于研究人员找到治疗和控制骨棘球蚴病的新策略和靶点。为进一步了解骨棘球蚴病,认清棘球绦虫在最终宿主和中间宿主中发育过程的分子基础至关重要,在细粒棘球绦虫、多房棘球绦虫中发现的miRNA在其各自宿主的表达调控中具有基因和发育阶段特异性。主要对miRNA作为骨棘球蚴病诊断标志物的研究进展进行综述。

Bone echinococcosis is usually caused by Echinococcus granulosus and E.multilocularis.People become infected when they eat food or water contaminated with the eggs.Treatment of bone echinococcosis usually includes surgery and medication,but the lengthy and costly treatment imposes a heavy burden on patients.MicroRNAs(miRNA)are known to be involved in a variety of biological processes and host-host interactions,including development,cell growth and death,lifespan-related target regulation,transcription,signal transduction,and cell motility,which will help us find new strategies and targets for the treatment and control of osteonechoconiosis.For further understanding of bone echinococcosis,it is important to understand the molecular basis of E.multilocularis development in both final and intermediate hosts.The miRNA found in E.granulosus and E.multilocularis have gene and developmental stage specificity in their respective host expression regulation.In this review paper,the progress of research on miRNA as a novel diagnostic marker for osteoblastic echinococcosis is reviewed.