聚氨酯低聚物对光固化树脂基质性能的影响

Effect of Poly-urethane Oligomer on Properties of Light-cured Dental Resin

目的:合成一种聚氨酯-二甲基丙烯酸酯低聚物(PU-MA),应用于牙科可见光固化树脂基质以改善其综合性能。方法:以BPA、IPDI和HEMA为原料合成PU-MA,并与POSS-MA、Bis-GMA/TEGDMA共混配制新型可见光固化树脂基质,通过物理-机械性能和体外细胞毒性检测,评价其综合性能;采用SPSS20.0统计软件对数据进行单因素和双因素方差分析。结果:20wt%PU-MA使树脂基质的挠曲强度达(124.51±6.00)MPa,高于ISO 4049要求的下限(≥90 MPa);吸水和溶解值为(25.93±1.47)μg/mm^(3)和(0.50±0.08)μg/mm^(3),低于ISO 4049要求的上限(吸水值≤40μg/mm^(3),溶解值≤7.5μg/mm^(3));体外细胞毒性试验表明,L929细胞增殖率大于90%,且细胞生长形态良好。结论:在一定条件下(对于甲基丙烯酸酯基树脂),PU-MA可有效提高传统树脂基质的力学性能,降低其吸水和溶解性,在改善复合树脂耐老化性能方面可能具有较好的应用潜力。

Objective:To improve the comprehensive performance of dental resin matrix through a new polyurethane-dimethacrylate oligomer(PU-MA).Methods:BPA,IPDI,and HEMA were used to synthesize the PU-MA,and the new dental resin matrix was prepared by combining the PU-MA with Bis-GMA/TEGDMA resin matrix reinforced by 5 wt%POSS-MA.The mechanical-physical properties and in vitro cytotoxicity were tested.Results:The flexible strength of PU-MA-20 was up to(124.51±6.00)MPa,which was higher than the minimum standard of ISO 4049(≥90 MPa);the water absorption and solubility were(25.93±1.47)μg/mm^(3) and(0.50±0.08)μg/mm^(3),which were lower than the maximum standard of ISO 4049(water absorption≤40μg/mm^(3),water solubility≤7.5μg/mm^(3)).The relative growth rate of PU-MA-20 was more than 90%and the L929 cell morphology performs well.Conclusion:For methacrylate based resin,PU-MA is conducive to improve the mechanical strength of traditional dental resin and decrease its water sorption and solubility,which indicates that it may have a good application potential in improving the aging resistance of composite resin.