基于配伍淫羊藿防治老年性疾病的药理机制研究进展

Research progress on pharmacological effects of compatible preparations of Epimedium brevicornu in the treatment of geriatric diseases

淫羊藿为小檗科植物的干燥叶,常用于肾阳虚衰、筋骨痿软等病症。中医以“君臣佐使”为原则,充分考虑药物的特性进行组方,合理配伍可以增加中药疗效,减少不良反应,中医称之为“相须”“相使”。我国人口老龄化已是社会难题,骨质疏松症等老年性疾病困扰着众多中老年患者。目前,有诸多学者针对淫羊藿及其活性成分的配伍制剂防治老年性疾病进行了较为深入的研究,但缺乏对此类研究的系统整理。因此,本研究结合近10年的文献报道,对淫羊藿及其活性成分的配伍制剂防治骨质疏松症、痴呆症、性功能障碍的药理机制研究进行综述,为淫羊藿制剂防治老年性疾病的应用开发提供参考,为中药的配伍研究提供思路。

Epimedium brevicornu is a dry leaf of berberidae,which is often used in kidney Yang deficiency.Traditional Chinese medicine takes full account of the characteristics of drugs to form prescriptions in a principle which is named Monarch,Minister,Assistant and Guide.Rational compatibility or prescription can not only increase curative effect,but also reduce adverse reactions.In traditional Chinese medicine,it is called"Xiangshu"and"Xiangzhi".The aging of Chinese population has become an increasingly serious social problem.Osteoporosis and other geriatric diseases are always bothering the elderly.In recent years,many scholars have made more in-depth research on the compatibility of epimedium and its active ingredients for the prevention and treatment of geriatric diseases,but there is a lack of comprehensive arrangement of such research.Therefore,this paper summarizes the research progress of the compatible preparations of epimedium and its active components in the treatment of osteoporosis,sexual dysfunction,and dementia by analyzing the literature in this decade,so as to provide reference for the development and application of Epimedium preparations in the treatment of geriatric diseases and provide ideas for the compatibility research of traditional Chinese medicine.