摘要
银屑病是一种由多因素诱发的慢性、复发性和炎症性皮肤病,典型临床表现为鳞屑性红斑或斑块,并可引起代谢综合征、心血管疾病和炎症性关节炎等多种并发症,严重影响患者生活质量。对银屑病发病机制的深入了解有助于发现新的治疗靶点及研发有效的新型治疗药物,因此具有重要的临床意义。本文综述了近年来银屑病发病机制及治疗药物研究的新进展。
Psoriasis is a chronic,recurrent,and inflammatory skin disease induced by multiple factors.Its typical clinical manifestation is scaly erythema or plaques,which can cause various complications such as metabolic syndrome,cardiovascular disease,and inflammatory arthritis,seriously affecting the quality of life of patients.A deep understanding of the pathogenesis of psoriasis is helpful to discover new therapeutic targets and develop effective new therapeutic drugs,thus having important clinical significance.This manuscript reviews the new advances in the pathogenesis and drug research of psoriasis in recent years.
作者
刘婧雯
朱蕾
LIU Jing-wen;ZHU Lei(Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China)
出处
《药学学报》
CAS
CSCD
北大核心
2023年第10期2942-2951,共10页
Acta Pharmaceutica Sinica
基金
中国医学科学院医学与健康科技创新工程(2021-I2M-1-005)
中央高水平医院临床科研业务费(2022-PUMCH-C-025)。
