观察胺碘酮治疗急诊冠心病快速心律失常的临床效果

Clinical effect of amiodarone in treatment of tachyarrhythmia in emergency coronary heart disease

目的观察胺碘酮治疗急诊冠状动脉粥样硬化性心脏病(冠心病)快速心律失常的临床效果。方法研究对象是以随机数字表法均分为参照、研究两组各30例的南阳南石医院急诊科冠心病快速心律失常患者,于2022年1月至2022年12月入院后均进行急诊抢救,并分别给予普罗帕酮及胺碘酮治疗,最后对比急诊治疗效果。结果研究组治疗总有效率(96.67%)高于参照组(80.00%)(P<0.05);症状消失时间(5.05±0.62)d、心电图恢复正常时间(8.57±1.42)d均短于参照组(7.37±0.79)d、(11.64±1.84)d(P<0.05);心率(HR)(83.45±7.17)次/min、左心室射血分数(LVEF)(55.38±5.91)%及左室舒张末期内径(LVEDD)(41.98±2.10)mm水平均低于参照组(95.12±7.83)次/min、(64.84±5.97)%、(52.17±2.69)mm(P<0.05);P-R及Q-T间期(152.38±9.91)ms、(42.72±3.65)ms高于参照组(146.20±8.44)ms、(39.58±3.72)ms(P<0.05);短阵心房颤动(87.38±7.51)次/24 h、室性期前收缩(723.05±18.15)次/24 h、房性期前收缩(505.04±17.14)次/24 h、房室交界性期前收缩(78.43±5.51)次/24 h均少于参照组(106.84±9.97)次/24 h、(1254.14±38.41)次/24 h、(975.17±27.06)次/24 h、(140.02±9.94)次/24 h(P<0.05)。研究组并发症发生率(13.33%)低于参照组(26.67%),差异无统计学意义(P>0.05)。结论将胺碘酮运用于急诊冠心病快速心律失常的治疗中不仅可以促进病情减轻,而且也有助于提高患者心功能,且使用安全性好,具有一定临床推广应用意义。

【Objective】To observe the clinical effect of amiodarone in the treatment of tachyarrhythmia in emergency coronary heart disease.【Methods】Patients with tachyarrhythmia of coronary heart disease who were admitted to the emergency department of Nanshi Hospital in Nanyang from January 2022 to December 2022 were included in the study.They were divided into two groups,30 cases in each group,by random number table method,and all received emergency rescue.At the same time,the reference group was given propafenone treatment,research group was given amiodarone treatment,and the efficacy was compared.【Results】The total effective rate of treatment in the study group(96.67%)was higher than that of the reference group(80.00%);the time for symptoms to disappear(5.05±0.62 d)and the time for ECG to return to normal(8.57±1.42 d)were shorter than those of the reference group(7.37±0.79 d,11.64±1.84 d);HR(83.45±7.17 times/min),LVEF(55.38%±5.91%)and LVEDD(41.98±2.10 mm)were lower than those of the reference group(95.12±7.83 times/min,64.84%±5.97%,52.17±2.69 mm);PR and QT intervals(152.38±9.91 ms,42.72±3.65 ms)were higher than those of the reference group(146.20±8.44 ms,39.58±3.72 ms);short bursts of atrial fibrillation(87.38±7.51 times/24h),ventricular premature contraction(723.05±18.15 times/24h),atrial premature contraction(505.04±17.14 times/24h),atrioventricular junctional premature contraction(78.43±5.51 times/24h)were less than the reference group(106.84±9.97 times/24h,1254.14±38.41 times/24h,975.17±27.06 times/24h,140.02±9.94 times/24h);the data comparison was statistically significant(P<0.05).The incidence of complications in the study group(13.33%)was lower than that in the reference group(26.67%),and the comparison was not statistically significant(P>0.05).【Conclusion】The application of amiodarone in the treatment of tachyarrhythmia in emergency coronary heart disease not only helps to speed up the disappearance of symptoms,but also can improve the cardiac function of patients,and the drug safety is high,which has clinical application value.