基于Meta分析的头孢他啶阿维巴坦治疗铜绿假单胞菌感染的疗效评价

Efficacy Evaluation of Ceftazidime-Avibactam in the Treatment of Pseudomonas Aeruginosa Infection Based on Meta-Analysis

目的:基于Meta分析方法,系统评价头孢他啶阿维巴坦(CAZ-AVI)治疗铜绿假单胞菌(PA)感染的疗效。方法:计算机检索PubMed、Embase、the Cochrane Library、Web of Science、中国知网、万方数据库及维普数据库,搜集有关CAZ-AVI治疗PA感染患者的随机对照试验。检索时限为建库至2023年1月。根据纳入和排除标准选取文献、提取数据并进行质量评价,应用RevMan 5.3软件进行Meta分析。结果:共纳入5项研究,共217例患者。Meta分析结果显示,CAZ-AVI与其他治疗方案的临床治愈率比较,差异无统计学意义(RR=0.93,95%CI=0.83~1.05,P=0.23)。结论:对于PA感染,CAZ-AVI的疗效与其他治疗方案相当,但需要更大样本的研究来进一步佐证。

OBJECTIVE:To systematically evaluate the efficacy of ceftazidime-avibactam(CAZ-AVI) in the treatment of Pseudomonas aeruginosa(PA) infection based on Meta-analysis.METHODS:PubMed,Embase,the Cochrane Library,Web of Science,CNKI,Wanfang Data and VIP database were electronically retrieved to collect the randomized controlled trials of CAZ-AVI in the treatment of patients with PA infection.The retrieval time was from the establishment of the database to Jan.2023.According to the inclusion and exclusion criteria,literature were selected,data were extracted and quality evaluation was conducted.RevMan 5.3 software was used for Meta-analysis.RESULTS:A total of 217 patients were included in 5 studies.Meta-analysis showed that the clinical cure rate of CAZ-AVI was not significantly different from other treatment schemes(RR=0.93,95%CI=0.83-1.05,P=0.23).CONCLUSIONS:For the infection induced by PA,the efficacy of CAZ-AVI is equivalent to that of other treatment schemes.Larger sample of researches are needed to further support this important issue.