摘要
目的:基于Meta分析方法,系统评价头孢他啶阿维巴坦(CAZ-AVI)治疗铜绿假单胞菌(PA)感染的疗效。方法:计算机检索PubMed、Embase、the Cochrane Library、Web of Science、中国知网、万方数据库及维普数据库,搜集有关CAZ-AVI治疗PA感染患者的随机对照试验。检索时限为建库至2023年1月。根据纳入和排除标准选取文献、提取数据并进行质量评价,应用RevMan 5.3软件进行Meta分析。结果:共纳入5项研究,共217例患者。Meta分析结果显示,CAZ-AVI与其他治疗方案的临床治愈率比较,差异无统计学意义(RR=0.93,95%CI=0.83~1.05,P=0.23)。结论:对于PA感染,CAZ-AVI的疗效与其他治疗方案相当,但需要更大样本的研究来进一步佐证。
OBJECTIVE:To systematically evaluate the efficacy of ceftazidime-avibactam(CAZ-AVI) in the treatment of Pseudomonas aeruginosa(PA) infection based on Meta-analysis.METHODS:PubMed,Embase,the Cochrane Library,Web of Science,CNKI,Wanfang Data and VIP database were electronically retrieved to collect the randomized controlled trials of CAZ-AVI in the treatment of patients with PA infection.The retrieval time was from the establishment of the database to Jan.2023.According to the inclusion and exclusion criteria,literature were selected,data were extracted and quality evaluation was conducted.RevMan 5.3 software was used for Meta-analysis.RESULTS:A total of 217 patients were included in 5 studies.Meta-analysis showed that the clinical cure rate of CAZ-AVI was not significantly different from other treatment schemes(RR=0.93,95%CI=0.83-1.05,P=0.23).CONCLUSIONS:For the infection induced by PA,the efficacy of CAZ-AVI is equivalent to that of other treatment schemes.Larger sample of researches are needed to further support this important issue.
作者
黄美佳
蔡方晴
刘彩玉
郑慧敏
林晓兰
李艺炫
许润恒
王凌
龚书榕
阮君山
HUANG Meijia;CAI Fangqing;LIU Caiyu;ZHENG Huimin;LIN Xiaolan;LI Yixuan;XU Runheng;WANG Ling;GONG Shurong;RUAN Junshan(School of Pharmacy,Fujian Medical University,Fuzhou 350122,China;School of Pharmacy,Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;School of Clinical Medicine,Fujian Medical University,Fuzhou 350122,China;Dept.of Pharmacy,Fujian Provincial Hospital,Shengli Clinical Medical College of Fujian Medical University,Fuzhou 350001,China;Molecular Biology Laboratory of Traditional Chinese Medicine,Fujian Provincial Hospital,Fuzhou 350001,China;The Third Department of Critical Medicine,Fujian Provincial Hospital,Fuzhou 350001,China)
出处
《中国医院用药评价与分析》
2023年第9期1109-1113,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
基金
福建省卫生健康科研人才培养项目(No.2019-ZQN-12)。