非那雄胺对前列腺增生患者经尿道前列腺钬激光剜除术后尿动力学指标及IPSS评分的影响

Effect of finasteride on urodynamic indexes and IPSS score after transurethral holmium laser enucleation of prostate in patients with benign prostate hyperplasia

目的探讨非那雄胺对前列腺增生(BPH)患者经尿道前列腺钬激光剜除术(HoLEP)后尿动力学指标及国际前列腺症状评分(IPSS评分)的影响。方法选取2020年1月至2022年12月该院收治的86例BPH患者作为研究对象,采用随机数字表法分为观察组和对照组,每组各43例。两组均进行HoLEP治疗,观察组在此基础上给予非那雄胺治疗,术后连续治疗4周。结果术后4周,两组最大尿流率(Qmax)均高于术前,残余尿量(RUV)均低于术前,且观察组Qmax高于对照组,RUV低于对照组,差异均有统计学意义(P<0.05);术后4周,两组IPSS评分均低于术前,且观察组低于对照组,差异均有统计学意义(P<0.05);术后4周,两组胰岛素样生长因子-1、肿瘤坏死因子-α、白细胞介素-6水平均低于术前,且观察组低于对照组,差异均有统计学意义(P<0.05)。两组术后均未见严重不良反应。结论非那雄胺用于BPH患者HoLEP后治疗,可有效调节炎症指标,促进术后前列腺症状及尿动力学指标的改善。

Objective To investigate the effect of finasteride on urodynamics indexes and International Prostate Symptom Score(IPSS score)after transurethral holmium laser enucleation of prostate(HoLEP)in patients with benign prostate hyperplasia(BPH).Methods A total of 86 patients with BPH admitted to the Affiliated Hospital of Jiangxi University of Traditional Chinese Medicine from January 2020 to December 2022 were selected as the research objects,which were divided into observation group and control group by random number table method,with 43 cases in each group.Both groups were treated with HoLEP,and the observation group was treated with finasteride on the basis of HoLEP for 4 weeks.Results At 4 weeks after surgery,the maximum urine flow rate(Qmax)and residual urine volume(RUV)in both groups were higher than those before surgery,and the Qmax in observation group was higher than that in control group,the RUV in observation group was lower than that in control group,with statistical significance(P<0.05).At 4 weeks after surgery,IPSS scores in both groups were lower than those before surgery,and which in observation group was lower than that in control group,with statistical significance(P<0.05).At 4 weeks after surgery,the levels of insulin-like growth factor-1,tumor necrosis factor-αand interleukin-6 in both groups were lower than those before surgery,and those in the observation group were lower than those in control group,with statistical significance(P<0.05).There was no serious adverse reaction in both groups.Conclusion Finasteride can be used after HoLEP treatment of BPH patients,which can effectively regulate inflammatory indexes and promote the improvement of postoperative prostate symptoms and urodynamic indexes.