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降压药物基因多态性在高血压患者中的分布 被引量:2

Distribution of antihypertensive drug gene polymorphism in patients with hypertension
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摘要 目的对陕西省宝鸡地区高血压患者降压药物相关基因的基因型种类进行回顾性分析,明确与降压药物相关的基因突变率。方法选取2022年1-12月在陕西省宝鸡市中医医院就诊的高血压患者224例为研究对象,采用飞行时间质谱仪对高血压药物代谢、疗效或不良反应相关的11个基因位点进行检测,然后进行检测结果的基因多态性分析。结果各基因分布频率符合Hardy-Weinberg平衡。男性与女性CYP2D6*1、*5、*10,ACE I/D,SLCO1B1 c.388A>G的基因型分布频率比较,差异有统计学意义(P<0.05),其余药物基因型分布频率比较,差异无统计学意义(P>0.05)。CYP2D6*1、*5、*10,CYP3A5*1、*3,SLCO1B1 c.388A>G在不同年龄段的高血压患者中基因型分布频率比较,差异有统计学意义(P<0.05);其余药物基因型分布频率在不同年龄段的患者中比较,差异无统计学意义(P>0.05)。结论对高血压患者进行降压药物基因型种类检测,可以为临床医生对患者制订个体化治疗方案提供辅助性的指导,具有重要的临床价值。 Objective To review the genotypes of antihypertensive drugs-related genes in hypertensive patients in Baoji area,Shaanxi Province,and to clarify the gene mutation rate associated with antihypertensive drugs.Methods A total of 224 hypertensive patients who visited Baoji City Hospital of Traditional Chinese Medicine from January to December 2022 were selected as objects and the 11 gene locus related to drug metabolism,efficacy or adverse effects of hypertension were tested by time-of-flight mass spectrometry,followed by gene polymorphism analysis of the test results.Results The distribution frequency of each gene corresponded to Hardy-Weinberg equilibrium.There was statistical significance on the distribution frequency of CYP2D6*1,*5,*10,ACE I/D,SLCO1B1 c.388A>G genotype between male and female(P<0.05),while there was no statistical significance on the distribution frequency of other drug genotypes(P>0.05).There were significant differences on the distribution frequency of CYP2D6*1,*5,*10,CYP3A5*1,*3,SLCO1B1 c.388A>G in hypertension patients with different ages(P<0.05),while there was no significant difference on the distribution frequency of other drug genotypes among different age groups(P>0.05).Conclusion Genetic testing of antihypertensive drugs in hypertensive patients can provide auxiliary guidance for clinical doctors to develop personalized treatment plans for patients,and has important clinical value.
作者 冯淳 甄拴平 王华 邓明星 王慧 姚杨 FENG Chun;ZHEN Shuanping;WANG Hua;DENG Mingxing;WANG Hui;YAO Yang(Department of Clinical Laboratory,Baoji City Hospital of Traditional Chinese Medicine,Baoji,Shaanxi 721001,China;Department of Reproductive Medicine,Baoji Maternal and Child Health Hospital,Baoji,Shaanxi 721004,China)
出处 《检验医学与临床》 CAS 2023年第22期3290-3296,共7页 Laboratory Medicine and Clinic
基金 陕西省宝鸡市卫生健康科研项目(2021-42)。
关键词 基因多态性 高血压 药物基因组学 个体化用药 gene polymorphism hypertension pharmacogenomics individualized medication
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