沙库巴曲缬沙坦联合重组人脑利钠肽治疗老年慢性心力衰竭的效果及对心肌纤维化指标的影响

Effect of sacubitril valsartan combined with recombinant human brain natriuretic peptide in the treatment of elderly patients with chronic heart failure and its influence on myocardial fibrosis indexes

目的探讨沙库巴曲缬沙坦联合重组人脑利钠肽治疗老年慢性心力衰竭的效果。方法选取2019年4月至2021年11月收治的120例老年慢性心力衰竭患者为研究对象,按照随机数字表法将其分为对照组和观察组,各60例。对照组采用常规治疗+重组人脑利钠肽治疗,观察组在对照组基础上加沙库巴曲缬沙坦治疗。比较两组的治疗效果。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的转化生长因子-β_(1)(TGF-β_(1))、半乳糖凝集素-3(Gal-3)及结缔组织生长因子(CTGF)水平低于对照组(P<0.05)。治疗后,观察组的左心室射血分数(LVEF)高于对照组,心排血量(CO)、左心室舒张末内径(LVEDD)及室间隔厚度(IVST)小于对照组(P<0.05)。治疗后,观察组的明尼苏达心力衰竭生活质量问卷(MLHFQ)各维度评分低于对照组(P<0.05)。结论沙库巴曲缬沙坦联合重组人脑利钠肽治疗老年慢性心力衰竭患者的效果较好。

Objective To investigate the effect of sacubitril valsartan combined with recombinant human brain natriuretic peptide in the treatment of elderly patients with chronic heart failure.Methods A total of 120 elderly patients with chronic heart failure admitted from April 2019 to November 2021 were selected as the research objects and divided into control group and observation group according to the random number table method,with 60 cases in each group.The control group was treated with conventional therapy+recombinant human brain natriuretic peptide,and the observation group was treated with sacubitril valsartan on the basis of the control group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of transforming growth factor-β_(1)(TGF-β_(1)),galectin-3(Gal-3)and connective tissue growth factor(CTGF)in the observation group were lower than those in the control group(P<0.05).After treatment,the left ventricular ejection fraction(LVEF)in the observation group was higher than that in the control group,and the cardiac output(CO),left ventricular end diastolic diameter(LVEDD)and interventricular septum thickness(IVST)were less than those in the control group(P<0.05).After treatment,the scores of each dimension of Minnesota Living with Heart Failure Questionnaire(MLHFQ)in the observation group were lower than those in the control group(P<0.05).Conclusion Sacubitril valsartan combined with recombinant human brain natriuretic peptide in the treatment of elderly patients with chronic heart failure has better effect.