奥扎格雷钠联合阿司匹林治疗脑梗死患者的临床效果

Clinical effect of ozagrel sodium combined with aspirin in the treatment of patients with cerebral infarction

目的分析奥扎格雷钠联合阿司匹林治疗脑梗死患者的临床效果。方法选取2019年9月至2021年8月收治的82例脑梗死患者为研究对象,以随机数字法将其分为常规组和观察组,每组41例。两组均给予常规对症治疗,在此基础上,常规组给予阿司匹林肠溶片治疗,观察组在常规组基础上加用注射用奥扎格雷钠治疗。比较两组的治疗效果。结果观察组的治疗总有效率显著高于常规组(P<0.05)。治疗后,观察组的肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、白细胞介素-17(IL-17)水平及α颗粒膜糖蛋白(CD62p)、溶酶体颗粒膜糖蛋白(CD63)、血小板-单核细胞聚集体(PMA)显著低于常规组(P<0.05)。治疗后,观察组的凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)显著长于常规组(P<0.05)。治疗后,观察组的血流速度最大值(V_(max))、血流速度最小值(V_(min))、平均血流量(Q_(mean))均显著高于常规组,外周阻力(RV)显著低于常规组(P<0.05)。两组患者治疗期间的药物不良反应总发生率无显著差异(P>0.05)。结论奥扎格雷钠联合阿司匹林治疗脑梗死患者可取得理想的治疗效果。

Objective To analyze the clinical effect of ozagrel sodium combined with aspirin in the treatment of patients with cerebral infarction.Methods A total of 82 patients with cerebral infarction admitted from September 2019 to August 2021 were selected as the study objects and divided into conventional group and observation group by random number method,with 41 cases in each group.Both groups were given conventional symptomatic treatment,on the basis of which,the conventional group was treated with aspirin enteric-coated tablets,and the observation group was treated with ozagrel sodium for injection on the basis of the conventional group.The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the observation group was significantly higher than that in the conventional group(P<0.05).After treatment,the tumor necrosis factor-α(TNF-α),high-sensitivity C-reactive protein(hs-CRP),interleukin-17(IL-17)levels and alpha granule membrane glycoprotein(CD62p),lysosomal granule membrane glycoprotein(CD63)and platelet-monocyte aggregates(PMA)in the observation group were significantly lower than those in the conventional group(P<0.05).After treatment,prothrombin time(PT)and activated partial thromboplastin time(APTT)in the observation group were significantly longer than those in the conventional group(P<0.05).After treatment,maximum blood flow velocity(V_(max)),minimum blood flow velocity(V_(min))and mean blood flow(Q_(mean))in the observation group were significantly higher than those in the conventional group,vascular resistance(RV)was significantly lower than that in the conventional group(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups during treatment(P>0.05).Conclusion Ozagrel sodium combined with aspirin in the treatment of patients with cerebral infarction can achieve ideal therapeutic effect.