肠神经胶质细胞在炎症性肠病中的作用研究进展

Advances in the Study of the Role of Enteric Glial Cells in Inflammatory Bowel Disease

近年来,肠神经胶质细胞(enteric glial cell,EGC)在炎症性肠病(inflammatory bowel disease,IBD)发病机制中引起广泛关注。在IBD患者中,肠道EGC通过释放细胞因子和介质参与调节肠道炎症反应,EGC与肠道上皮细胞、免疫细胞和神经元等相互作用,参与调节肠道的免疫平衡和功能,EGC在炎症性肠病治疗中的潜在应用,调控和干预EGC有望为治疗提供新思路和策略。

In recent years,enteric glial cells(EGC)have attracted widespread attention in the pathogenesis of inflammatory bowel disease(IBD).In IBD patients,intestinal EGCs are involved in the regulation of intestinal inflammatory responses through the release of cytokines and mediators,and EGCs interact with intestinal epithelial cells,immune cells,and neurons to participate in the regulation of intestinal immune homeostasis and function.The potential application of EGC in the treatment of inflammatory bowel disease,modulation and intervention of EGC is expected to provide new ideas and strategies for treatment.