血清尿酸、血浆脑钠肽、心肌酶谱与急性心肌梗死患者经皮冠脉介入术后再灌注心律失常的关系

Relationship between serum uric acid,plasma cerebral natriuretic peptide,myocardial enzyme profile and reperfusion arrhythmia in patients with acute myocardial infarction after percutaneous coronary intervention

目的研究分析血清尿酸(UA)、血浆脑钠肽(BNP)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、谷草转氨酶(AST)、肌酸激酶(CK)与急性心肌梗死患者经皮冠脉介入术(PCI)后再灌注心律失常(RA)的关系。方法回顾性选取2018年1月至2022年6月江西省婺源县人民医院收治的80例行PCI手术治疗的急性心肌梗死患者作为研究对象,根据患者术后有无发生RA情况,将其分为RA组(40例)与非RA组(40例)。比较两组患者血清UA、BNP、CK-MB、LDH、AST、CK指标变化,分析其与(RA)关系。结果RA组患者血清UA、BNP水平高于非RA组,差异有统计学意义(P<0.05)。RA组患者CK-MB、LDH、AST、CK水平均高于非RA组,差异有统计学意义(P<0.05)。Spearman分析结果显示,血清UA、BNP、心肌酶谱与PCI术后RA呈正相关,有统计学意义(P<0.05)。结论在临床对急性心肌梗死患者行PCI手术治疗后,患者血清UA、BNP、心肌酶谱变化与RA具有相关性,可通过调节PCI术后患者的血清UA、BNP、心肌酶谱水平,以降低患者PCI术后发生RA的风险,提升患者临床疗效,可在实践中推广应用。

Objective To investigate the relationship between serum uric acid(UA),plasma cerebral natriuretic peptide(BNP),creatine kinase isoenzyme(CK-MB),lactate dehydrogenase(LDH),glutamic oxalacetic transaminase(AST),creatine kinase(CK)and reperfusion arrhythmia(RA)after percutaneous coranary intervention(PCI)in patients with acute myocardial infarction.Methods Eighty patients with acute myocardial infarction who underwent PCI treatment in Wuyuan County People's Hospital of Jiangxi Province from January 2018 to June 2022 were retrospectively selected as the study objects.According to whether the patients had RA after surgery,they were divided into RA group(40 cases)and non-RA group(40 cases).The changes of serum UA,BNP,CK-MB,LDH,AST and CK were compared between the two groups,and their relationship with RA was analyzed.Results The serum UA and BNP levels of the two groups were compared after PCI.The serum UA and BNP levels of the RA group were higher than those of the non-RA group,and the differences were statistically significant(P<0.05).The levels of CK-MB,LDH,AST and CK in the RA group were higher than those in the non-RA group,with statistical significance(P<0.05).Spearman analysis showed that serum UA,BNP and myocardial enzyme profile were positively correlated with RA after PCI,with statistical significances(P<0.05).Conclusion In clinical practice of patients with acute myocardial infarction undergoing PCI procedure,the changes of serum UA,BNP,and myocardial zymography in patients have correlation with RA,which can be promoted in practice by regulating the levels of serum UA,BNP,and myocardial zymography in patients after PCI to reduce the risk of patients developing RA after PCI and improve the clinical efficacy of patients.