肝功能相关指标对老年人窦性心动过缓的影响因素分析

Analysis of the impact of gender and liver function-related index on sinus bradycardia

目的探讨老年人发生窦性心动过缓的影响因素,为预防窦性心动过缓的发生提供参考依据。方法纳入广西壮族自治区南宁市东葛社区65岁以上老年体检者(331例),根据心电图检查结果将受检者分为窦性心动过缓组(155例)和正常组(176例),并对窦性心动过缓的影响因素进行分析,发现性别在两组中存在显著差异,因此进行性别分层,分别分析影响男性和女性发生窦性心动过缓的相关因素。结果本研究共包括331例参与者,其中男性121例(36.6%),女性210例(63.4%),中位年龄71.4(68.0,75.9)岁;窦性心动过缓组男性80例(51.6%),女性75例(48.4%),正常组中男性41例(23.3%),女性135例(76.7%),男性发生窦性心动过缓的比例高于女性,差异具有统计学意义(P<0.001);吸烟(P=0.018)、血清谷草转氨酶(AST)(P=0.018)、血清肌酐(Cr)(P=0.003)的差异也具有统计学意义。按性别分层后,男性ALT水平的差异具有统计学意义(P=0.046),女性AST水平的差异具有统计学意义(P=0.009)。结论老年人窦性心动过缓多发于男性,肝功能相关指标ALT与老年男性发生窦性心动过缓相关,AST与老年女性发生窦性心动过缓明显相关。

Objective To explore the influencing factors of sinus bradycardia in the elderly people and provide reference for the prevention of sinus bradycardia.Methods A total of 331 elderly participants aged 65 years and above from Dongge Community,Nanning,Guangxi Zhuang Autonomous Region were included in this study.Based on the results of electrocardiogram examination,the participants were divided into the sinus bradycardia group(155 cases)and the normal group(176 cases).The influencing factors of sinus bradycardia were analyzed,and significant differences were found in gender between the two groups.Therefore,gender stratification was conducted to analyze the related factors affecting the occurrence of sinus bradycardia in males and females separately.Results A total of 331 participants were included in this study,with 121 males(36.6%)and 210 females(63.4%).The median age was 71.4(68.0,75.9)years old.In the sinus bradycardia group,there were 80 males(51.6%)and 75 females(48.4%).While in the normal group,there were 41 males(23.3%)and 135 females(76.7%).The proportion of males with sinus bradycardia was higher than that of females,and the difference was statistically significant(P<0.001).Differences in smoking(P=0.018),aspartate aminotransferase(AST)level(P=0.018),and serum creatinine(Cr)level(P=0.003)were also statistically significant.After gender stratification,the difference in ALT level was statistically significant in males(P=0.046),and the difference in AST level was statistically significant in females(P=0.009).Conclusion Sinus bradycardia is more common in elderly males,and the liver function index ALT is associated with sinus bradycardia in elderly males,while AST is significantly correlated with sinus bradycardia in elder-ly females.