亨廷顿舞蹈病突发精神障碍1例报道并文献复习

Report of 1 Case of Sudden Mental Disorder of Huntington's Disease and Literature Review

目的:探讨亨廷顿舞蹈病(H untington disease,HD)患者临床特点,特别是精神障碍方面,依据对精神症状的了解提高H D疾病的诊断率。方法:在患者知情、自愿的原则下,收集2022年1月河北北方学院附属第一医院神经内一科收治的1名H D患者的临床资料,进行相关文献复习,并进行随访。结果:该患者家族中有2人已经出现肢体不自主运动、行走不稳、暴躁及焦虑等精神症状,此先证者突发精神障碍,CGA拷贝数为43次,HAMA评分:16分,HAMD评分:18分,通过相关文献复习了解到精神症状可能比运动症状早10年。结论:HD的早期诊断十分困难,其中家族史很重要,早期精神症状、影像学及病理学等也同样重要,HD患者的早期诊断对早期预防、改善预后及提高患者生活质量等均有重大意义。

Objective:To Explore the clinical characteristics of Huntington's disease patients,especially mental disorders,and improve the diagnosis rate of HD diseases based on understanding of psychiatric symptoms.Methods:In January 2022,under the principle of pa-tients informed and voluntary,the clinical data of one HD patient receiving a section of the first hospital affiliated with the first hospital,Hebei Northern College,will be collected,revisited and followed up.Results:Two of the patient's family have psychiatric symptoms such as physical involuntary movement,walking instability,irritation and anxiety,this forensic witness sudden mental disorder,its CGA copy number is 43 times,HAMA score:16,HAMD score:18,through the relevant literature review to learn that psychiatric symptoms may be 10 years earlier than motor symptoms.Conclusion:Early diagnosis of HD is very difficult,of which family history is important,early psychiatric symptoms,imaging and pathology are equally important,and early diagnosis of HD patients is of great significance to early prevention,improvement of prognosis and improvement of patients’quality of life.