血清脂蛋白a在高级别浆液性卵巢癌中的临床应用价值

Clinical utility of serum lipoprotein A in high-grade serous ovarian cancer

目的 探究血清脂蛋白a[Lp(a)]在高级别浆液性卵巢癌中的临床应用价值。方法 选取2020年1月至2022年6月安徽省肿瘤医院初治的75例高级别浆液性卵巢癌患者为实验组,70例卵巢良性病变患者为对照组,分析两组患者血清总胆固醇、三酰甘油、高密度脂蛋白、低密度脂蛋白及Lp(a)的水平差异;进一步分析Lp(a)水平与卵巢癌临床分期的关联;基于生物信息学分析LPA基因与卵巢癌分期和预后的关联。结果 两组患者总胆固醇、三酰甘油、高密度脂蛋白和低密度脂蛋白水平比较,差异均无统计学意义(P>0.05)。实验组患者Lp(a)水平为(379.95±296.10)mg/L,对照组为(163.59±153.87)mg/L,差异有统计学意义(P<0.001);Ⅲ~Ⅳ期卵巢癌患者Lp(a)水平为(399.12±305.69)mg/L,Ⅰ~Ⅱ期患者为(214.07±185.68)mg/L,差异有统计学意义(P<0.05);生物信息学分析结果显示,LPA基因表达与卵巢癌分期、化疗疗效和预后密切相关。结论 Lp(a)水平在卵巢癌患者血清中显著升高,且LPA基因表达与肿瘤分期、化疗疗效和预后相关,具有潜在的临床应用价值。

Objective To explore the application value of serum lipoprotein a[Lp(a)]in high-grade serous ovarian cancer.Methods A total of 75 high-grade serousovarian cancer patients(experimental group)and 70 patients with benign ovarian diseases(control group)were selected in Anhui Cancer Hospital from January 2020 to June 2022.Firstly,we analyzed the levels of total cholesterol,triglyceride,high density lipoprotein,low density lipoprotein and Lp(a)in these patients.Then the association between the Lp(a)level and clinical stage was analyzed in ovarian cancer.Finally,bioinformatics was performed to investigate the correlation between LPA expression and the stage,prognosis.Results No statistical difference was observed for the levels of total cholesterol,triglyceride,high density lipoprotein and low density lipoprotein between the experimental and control groups.The Lp(a)level in the experimental group(379.95±296.10)mg/L was significantly higher than that in the control group(163.59±153.87 mg/L)(P<0.001).Moreover,Lp(a)levels were significantly higher in stage Ⅲ~Ⅳ(399.12±305.69mg/L)ovarian cancer patients than in stage Ⅰ~Ⅱ(214.07±185.68)mg/L patients(P<0.05).Finally,the results of bioinformatics analysis showed that LPA expression was closely related with clinical stage,chemotherapy efficacy and prognosis of ovarian cancer.Conclusions Serum Lp(a)level significantly rises in patients with ovarian cancer.More importantly,LPA expression is correlated with clinical stage,therapeutic efficacy and prognosis of ovarian cancer,suggesting its potential clinical application value for ovarian cancer.