脑胶质瘤组织CMTM1、ME2表达与临床病理特征和复发的关系研究

Study of the Relationship between CMTM1 and ME2 Expression in Cerebral Gliomas Tissue and Clinicopathological Features and Recurrence

目的:探讨脑胶质瘤组织含CKLF样MARVEL跨膜结构域的蛋白1(CMTM1)、苹果酸酶2(ME2)表达与临床病理特征和复发的关系。方法:选取2018年1月~2021年1月徐州医科大学附属医院接受切除手术的92例脑胶质瘤患者,根据术后是否复发分为复发组和未复发组。采用免疫组化法检测脑胶质瘤组织和瘤旁组织CMTM1、ME2表达,分析二者与临床病理特征的关系,采用多因素Logistic回归分析脑胶质瘤患者术后复发的影响因素。结果:与瘤旁组织比较,脑胶质瘤组织中CMTM1、ME2阳性表达率升高(P<0.05)。不同分化程度、世界卫生组织(WHO)中枢神经系统肿瘤分类脑胶质瘤组织中CMTM1、ME2阳性表达率比较,差异有统计学意义(P<0.05)。随访2年,92例脑胶质瘤患者术后复发率为47.83%(44/92)。多因素Logistic回归分析显示,低分化、WHO中枢神经系统肿瘤分类Ⅲ~Ⅳ级、部分切除和CMTM1、ME2阳性表达为脑胶质瘤患者术后复发的独立危险因素(P<0.05)。结论:脑胶质瘤组织中CMTM1、ME2阳性表达率升高,与分化程度、WHO中枢神经系统肿瘤分类等级和术后复发有关,可能成为脑胶质瘤患者术后复发的辅助评估指标。

Objective:To investigate the relationship between the expression of CKLF like MARVEL transmembrane domain containing 1(CMTM1)and malic enzyme 2(ME2)in cerebral gliomas tissue and their clinicopathological features and recurrence.Methods:92 patients with cerebral gliomas who underwent surgical resection in Affiliated Hospital of Xuzhou Medical University from January 2018 to January 2021 were selected,and they were divided into recurrence group and non-recurrence group according to whether they recurred after surgery.The expression of CMTM1 and ME2 in cerebral glioma tissue and paraneoplastic tissue were detected by immunohistochemistry.The relationship between the two and clinical pathological characteristics were analyzed,and the influencing factors of postoperative recurrence in patients with cerebral gliomas was analyzed by multivariate Logistic regression.Results:Compared with the paraneoplastic tissue,the positive expression rates of CMTM1 and ME2 in cerebral gliomas tissue increased(P<0.05).There were statistically significant difference in the positive expression rates of CMTM1 and ME2 in cerebral gliomas tissue with different degrees of differentiation and World Health Organization(WHO)classification of central nervous system tumors(P<0.05).Following up for 2 years,the postoperative recurrence rate of 92 cerebral glioma patients was 47.83%(44/92).Multivariate logistic regression analysis showed that low differentiation,WHO classification of central nervous system tumors grade was III to IV,partial resection,and positive expression of CMTM1 and ME2 were independent risk factors for postoperative recurrence in patients with cerebral gliomas(P<0.05).Conclusion:The increase in the positive expression rates of CMTM1 and ME2 in cerebral glioma tissue is related to the degree of differentiation,WHO classification of central nervous system tumors grade and postoperative recurrence,and may become auxiliary evaluation indicators for postoperative recurrence in patients with cerebral gliomas.