百蕊颗粒联合头孢替唑钠治疗急性支气管炎患儿的临床研究

Clinical Study of Bailui Granule Combined with Ceftezole Sodium in the Treatment of Children with Acute Bronchitis

目的:探讨百蕊颗粒联合头孢替唑钠治疗急性支气管炎患儿的效果。方法:根据随机数字表法将我院2020年4月~2022年1月期间收治的102例急性支气管炎患儿分为对照组(头孢替唑钠治疗)和观察组(百蕊颗粒联合头孢替唑钠治疗),各为51例。对比两组疗效、临床指标、血常规指标、血清炎症因子水平的变化情况和不良反应发生率。结果:与对照组相比,观察组的临床总有效率明显升高(P<0.05)。与对照组相比,观察组咳痰、气喘、肺部啰音、咳嗽等症状消失时间更短(P<0.05)。两组治疗7 d后白细胞计数、中性粒细胞百分比、淋巴细胞百分比均下降,观察组低于对照组同期(P<0.05)。两组治疗7 d后C反应蛋白(CRP)、白介素-1β(IL-1β)、白介素-4(IL-4)、白介素-6(IL-6)、白介素-8(IL-8)、白介素-13(IL-13)均下降,观察组低于对照组同期(P<0.05)。两组患儿均未出现严重的不良反应情况。结论:百蕊颗粒联合头孢替唑钠治疗急性支气管炎患儿,可有效改善临床症状,减轻炎症反应,改善血常规指标。

Objective:To explore the effect of Bairui granule combined with ceftezole sodium in the treatment of children with acute bronchitis.Methods:102 children with acute bronchitis who were admitted to our hospital from April 2020 to January 2022 were divided into control group(ceftezole sodium treatment)and observation group(Bairui granule combined with ceftezole sodium treatment)according to random number table method,with 51 cases in each group.The curative effects,clinical indicators,blood routine indicators,serum inflammatory factor levels changes and the incidence of adverse reactions were compared in the two groups.Results:Compared with the control group,the total clinical effective rate in the observation group was significantly increased(P<0.05).Compared with the control group,sputum,asthma,pulmonary rales,cough and other symptoms disappeared time in the observation group were shorter(P<0.05).7 d after treatment,the white blood cell count,neutrophil percentage and lymphocyte percentage in the two groups were decreased,and the observation group was lower than the control group in the same period(P<0.05).7 d after treatment,C-reactive protein(CRP),interleukin-1β(IL-1β),interleukin-4(IL-4),interleukin-6(IL-6),interleukin-8(IL-8)and interleukin-13(IL-13)in the two groups were decreased,and the observation group was lower than the control group in the same period(P<0.05).There were no serious adverse reactions in the two groups.Conclusion:Bairui granule combined with ceftezole sodium in the treatment of children with acute bronchitis can effectively improve clinical symptoms,reduce inflammatory reaction and improve blood routine indicators.